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首页> 外文期刊>Journal of International Medical Research >Association of Interleukin-11 with Mortality in Patients with Spontaneous Basal Ganglia Haemorrhage
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Association of Interleukin-11 with Mortality in Patients with Spontaneous Basal Ganglia Haemorrhage

机译：白细胞介素-11与自发基底神经节出血患者死亡率的关联

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摘要

This study evaluated interleukin (IL)-11 as an independent prognostic marker of mortality following intracerebral haemorrhage (ICH). Plasma IL-11 levels in patients with ICH were significantly higher than in healthy controls. Multivariate analysis indicated that plasma IL-11 level was an independent predictor for mortality within 1 week of ICH onset and was positively associated with haematoma volume. Receiver operating characteristic curve analysis identified that a baseline plasma IL-11 level > 20.9 pg/ml predicted mortality within 1 week of ICH onset with 81.2% sensitivity and 74.1% specificity. The area under the curve for IL-11 level was significantly smaller than that for the Glasgow Coma Scale score, but similar to that for haematoma volume. IL-11 did not, however, significantly improve the predictive value of the Glasgow Coma Scale or haematoma volume. Thus, IL-11 may be considered as a new independent prognostic marker of mortality and an additional valuable tool for risk stratification and decision-making in the acute phase of ICH.
机译：该研究评估了白细胞介素（IL）-11作为脑内出血后死亡率的独立预后标志物（ICH）。 ICH患者的血浆IL-11水平明显高于健康对照。多变量分析表明，血浆IL-11水平是ICH发病1周内死亡率的独立预测因子，并且与血肿体积呈正相关。接收器操作特征曲线分析确定了基线血浆IL-11水平> 20.9pg / mL在ICH发作后1周内预测死亡率，敏感度为81.2％和74.1％。 IL-11水平曲线下的面积显着小于Glasgow Coma比分评分，但与血肿体积相似。然而，IL-11没有显着改善Glasgow Coma Scale或血肿体积的预测值。因此，IL-11可以被认为是一种新的独立预后标记的死亡率和额外的有价值工具，用于ICH的急性期的风险分层和决策。

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