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首页> 外文期刊>Journal of International Medical Research >Experimental Study of COX-2 Selective and Traditional Non-steroidal Anti-inflammatory Drugs in Total Hip Replacement
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Experimental Study of COX-2 Selective and Traditional Non-steroidal Anti-inflammatory Drugs in Total Hip Replacement

机译：Cox-2选择性和传统非甾体抗炎药的实验研究总髋关节置换

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摘要

This study investigated the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on peri-operative blood loss during elective total hip replacement. Patients were randomized to receive enteric-coated diclofenac 50 mg (n = 18), rofecoxib 12.5 mg (n = 17) or placebo (n = 16) administered orally three times daily for 2 weeks prior to surgery. Severe adverse effects resulting in discontinuation of trial participation occurred in six patients in the diclofenac group, five patients in the rofecoxib group and two patients in the placebo group; all drop-outs occurred at various times after surgery. Compared with placebo, peri-operative blood loss increased by 32% in the diclofenac group and by 7% in the rofecoxib group. Total mean ± SD blood loss was 1040 ± 136 ml in the diclofenac group, 844 ± 83 ml in the rofecoxib group and 789 ± 82 ml in the placebo group. Thus, administering a non-selective NSAID 2 weeks prior to elective total hip replacement significantly increases peri-operative blood loss.
机译：本研究调查了非甾体抗炎药（NSAID）对选修总髋关节置换期间血液损失的影响。患者被随机化接受肠涂覆的双氯芬酸50mg（n = 18），ROFecoxib 12.5mg（n = 17）或安慰剂（n = 16）在手术前2周在手术前2周给药三次。在双氯芬酸群组中，六名患者中停止试用的严重不良反应发生在六六叶菌中的六名患者，罗福克昔布群组和安慰剂组中的两名患者;手术后各次出现所有辍学。与安慰剂相比，双氯芬酸组的血液损失增加了32％，在罗福昔布基团中增加了7％。双氯芬酸基团的总平均值±SD损失为1040±136ml，在ROFecoxib组中844±83ml，安慰剂组中789±82ml。因此，在选修总髋关节置换前2周给药2周，显着提高了Peri操作失血。

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