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首页> 外文期刊>Journal of International Medical Research >Characteristic Genotypes of Vascular Endothelial Growth Factor are Susceptible to Ascites in Patients with Cirrhosis
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Characteristic Genotypes of Vascular Endothelial Growth Factor are Susceptible to Ascites in Patients with Cirrhosis

机译：血管内皮生长因子的特征基因型易患肝硬化患者的腹水

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This study was designed to investigate whether different vascular endothelial growth factor (VEGF) genotypes are associated with ascites formation in cirrhotic patients. Seventy cirrhotic patients were included in the study: 25 cirrhotic patients with ascites and 45 cirrhotic patients without ascites. Patient characteristics were investigated and compared between the two groups. With regard to VEGF genotype, 42 patients were C/C and 28 patients were T/T or C/T. The genotypes T/T or C/T were observed in 23 cases (51%) among the non-ascites group, but in only five cases (20%) among the ascites group. Serum levels of albumin and creatinine, and the VEGF genotypes were significantly different between the two groups. Multiple regression analysis showed that serum levels of creatinine and the VEGF genotypes were significantly correlated with ascites formation. Thus, it can be concluded that VEGF genotyping might be a valuable susceptibility marker for ascites formation in cirrhotic patients.
机译：本研究旨在研究不同的血管内皮生长因子（VEGF）基因型是否与肝硬化患者的腹水形成有关。七十个肝硬化患者均包含在研究中：25名肝硬化患者腹水和45名没有腹水的肝硬化患者。研究了患者特征，并在两组之间进行了比较。关于VEGF基因型，42例患者是C / C，28例患者是T / T或C / T.在非腹水组中的23例（51％）中观察到基因型T / T或C / T，但在腹水组中只有五种（20％）。两组之间的白蛋白和肌酐水平和VEGF基因型在显着差异。多元回归分析表明，血清肌酐水平和VEGF基因型与腹水形成显着相关。因此，可以得出结论，VEGF基因分型可能是肝硬化患者中腹水形成的有价值的敏感标志物。

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