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首页> 外文期刊>Journal of International Medical Research >Usefulness of metagenomic analysis in differential diagnosis for pyoderma gangrenosum
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Usefulness of metagenomic analysis in differential diagnosis for pyoderma gangrenosum

机译：Pyoderma gangrenosum鉴别诊断中的均衡诊断的有用性

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Pyoderma gangrenosum (PG) is a rare ulcerative inflammatory dermatosis easily confused with wound infection following surgery. There have been seven case reports of PG occurring after total knee arthroplasty (TKA), all of which used routine tissue culture for differential diagnosis. Notably, all previous cases involved delayed diagnosis. We report a case of PG after TKA where we used shotgun metagenomics for differential diagnosis. Metagenomic analysis is a new method that can be used for pathogen detection; it is fast and sensitive, compared with traditional culture. Early application of metagenomic analysis in cases of suspicious wound infection after surgery can detect the pathogen of the infection for target therapy; it can also exclude infection for differential diagnosis of non-infectious diseases, such as autoimmune disorders. This case is presented to support the use of metagenomic analysis by surgeons and physicians for early and rapid differential diagnosis in patients who exhibit postoperative wound infections.
机译：Pyoderma gangrenosum（pg）是一种罕见的溃疡性炎性皮肤病，容易与手术后伤口感染混淆。总膝关节关节成形术（TKA）发生了七个案例报告，其中所有使用常规组织培养的鉴别诊断。值得注意的是，所有以前的病例都涉及延迟诊断。我们在TKA之后举报了PG的案例，其中我们使用霰弹枪Metagenomics进行鉴别诊断。 Metagenomic分析是一种可用于病原体检测的新方法;与传统文化相比，它是快速和敏感的。在手术后可疑伤口感染病例的早期应用可以检测靶疗法感染的病原体;它还可以排除感染非传染病的鉴别诊断，如自身免疫障碍。本案例提出，支持在术后伤口感染的患者中使用外科医生和医生对外科医生和医生的使用。

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