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首页> 外文期刊>Journal of International Medical Research >Changes in serum serotonin levels in patients with acute coronary syndrome and stable angina undergoing percutaneous coronary intervention
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Changes in serum serotonin levels in patients with acute coronary syndrome and stable angina undergoing percutaneous coronary intervention

机译：急性冠状动脉综合征患者血清血清酮水平的变化，稳定冠状动脉介入

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Objective Activated platelets release serotonin, causing platelet aggregation and vasoconstriction. Serotonin levels were investigated in patients with acute coronary syndrome (ACS) and chronic stable angina (CSA) treated with percutaneous coronary intervention (PCI). Methods Consecutive patients undergoing PCI for either ACS or CSA were enrolled between July 2009 and April 2010. Patients were pre-treated with dual antiplatelet agents (aspirin and clopidogrel) before PCI. Serum serotonin levels, measured at baseline, pre- and post-PCI, and at 90 min, and 6, 12, 24 and 48 h following PCI, were compared between ACS and CSA groups. Results Sixty-three patients with ACS and 60 with CSA were included. Overall baseline characteristics were similar between the two groups. Serotonin levels at post-PCI (55.2?±?120.0 versus 20.1?±?24.0) and at peak (regardless of timepoint; 94.0?±?170.9 versus 38.8?±?72.3) were significantly higher in the ACS versus CSA group. At 90 min and 6, 24 and 48 h post-PCI, serum serotonin was numerically, but not significantly, higher in patients with ACS. Serotonin levels fluctuated in both groups, showing an initial rise and fall, rebound at 24 h and drop at 48 h post-PCI. Conclusions In patients undergoing PCI, serum serotonin was more elevated in patients with ACS than those with CSA, suggesting the need for more potent and sustained platelet inhibition, particularly in patients with ACS.
机译：目的活性血小板释放血清素，引起血小板聚集和血管收缩。用经皮冠状动脉介入（PCI）处理的急性冠状动脉综合征（ACS）和慢性稳定型心绞痛（CSA）的患者研究了血清素水平。方法在2009年7月和2010年4月之间招募了接受ACS或CSA的PCI的连续患者。在PCI之前用双抗血小板药物（阿司匹林和氯吡格雷）预处理。在ACS和CSA基团之间比较在基线，PCI前，PCI前和30分钟和6,12,24和48小时的基线中测量的血清血清酮水平。结果包括六十三名患有CSA的ACS和60名患者。两组之间的总体基线特征类似。在PCI后的血清素水平（55.2？±120.0与20.1？±24.0）和峰值（无论时间点; 94.0？±170.9与38.8？±72.3）在ACS与CSA组中显着高。在PCI后90分钟和6,24和48小时，血清血清素在数值上，但不显着，在ACS的患者中较高。两组中的血清素水平波动，显示出初始上升和下降，24小时反弹，并在PCI后48小时下降。结论在接受PCI的患者中，血清血清素比患有CSA的患者更升高，表明需要更有效和持续的血小板抑制，特别是在ACS患者中。

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