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首页> 外文期刊>Journal of International Medical Research >Novel coronavirus infection and acute kidney injury in two renal transplant recipients: a case report
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Novel coronavirus infection and acute kidney injury in two renal transplant recipients: a case report

机译：两种肾移植受者的新型冠状病毒感染和急性肾损伤：案例报告

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Background The causative virus of coronavirus disease 2019 (COVID-19) may cause severe fatal pneumonia. The clinical presentation includes asymptomatic infection, severe pneumonia, and acute respiratory failure. Data pertaining to acute renal injury due to COVID-19 in patients who have undergone renal transplantation are scarce. We herein report two cases of COVID-19 along with acute kidney injury following kidney transplantation. Case presentation: Two patients with COVID-19 underwent renal transplantation and were subsequently diagnosed with acute kidney injury. The first patient presented with progressive respiratory symptoms and acute renal injury. He was treated with diuretics and suspension of immunosuppressive therapy; however, the patient died. The second patient presented with respiratory tract symptoms, hypoxemia, and progressive deterioration of renal function followed by improvement. Her mycophenolate mofetil was stopped after admission, and tacrolimus was discontinued 10 days later. Moxifloxacin and methylprednisolone were continued in combination with albumin and gamma globulin infusion. A diuretic was administered, and prednisone was gradually reduced along with tacrolimus. The patient exhibited a satisfactory clinical recovery. Conclusion Patients who develop COVID-19 after kidney transplantation are at risk of acute kidney injury, and their prednisone, immunosuppressant, and gamma globulin treatment must be adjusted according to their condition.
机译：背景技术冠状病毒疾病2019（Covid-19）的致病病毒可能导致严重的致命肺炎。临床介绍包括无症状感染，严重的肺炎和急性呼吸衰竭。由于Covid-19导致肾移植的患者的急性肾损伤有关的数据是稀缺的。我们在此报告了两种Covid-19患者以及肾移植后急性肾损伤。案例介绍：两名Covid-19患者接受肾移植，随后被诊断为急性肾损伤。第一个患者呈现渐进式呼吸系统症状和急性肾损伤。他被利尿剂治疗和悬浮免疫抑制治疗;然而，患者死亡。第二例患者患有呼吸道症状，低氧血症和肾功能的渐进性劣化，然后改善。她的霉一蛋白Mofetil被入场后停止，并且在10天后停止了他克莫司。与白蛋白和γ球蛋白输注组合继续使用莫西沙星和甲基己酸甲酮。施用利尿剂，泼尼松与达克兰司逐渐减少。患者表现出令人满意的临床恢复。结论肾移植后开发Covid-19的患者面临急性肾损伤的风险，及其泼尼松，免疫抑制剂和γ球蛋白处理必须根据其病症进行调整。

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