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首页> 外文期刊>Journal of International Medical Research >Risk factors and prognosis of nosocomial pneumonia in patients undergoing extracorporeal membrane oxygenation: a retrospective study
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Risk factors and prognosis of nosocomial pneumonia in patients undergoing extracorporeal membrane oxygenation: a retrospective study

机译：体外膜氧合患者医院肺炎的危险因素及预后：回顾性研究

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Objective We aimed to examine the risk factors and prognosis of nosocomial pneumonia (NP) during extracorporeal membrane oxygenation (ECMO). Methods We retrospectively analyzed data of patients who received ECMO at the Affiliated Hangzhou Hospital of Nanjing Medical University between January 2013 and August 2019. The primary outcome was the survival-to-discharge rate. Results Sixty-nine patients who received ECMO were enrolled, median age 42 years and 26 (37.7%) women; 14 (20.3%) patients developed NP. The NP incidence was 24.7/1000 ECMO days. Patients with NP had a higher proportion receiving veno-venous (VV) ECMO (50% vs. 7.3%); longer ECMO support duration (276 vs. 140 hours), longer ventilator support duration before ECMO weaning (14.5 vs. 6 days), lower ECMO weaning success rate (50.0% vs. 81.8%), and lower survival-to-discharge rate (28.6% vs. 72.7%) than patients without NP. Multivariable analysis showed independent risk factors that predicted NP during ECMO were ventilator support duration before ECMO weaning (odds ratio [OR]?=?1.288; 95% confidence interval [CI]: 1.111–1.494) and VV ECMO mode (OR?=?10.970; 95% CI: 1.758–68.467). Conclusion NP during ECMO was associated with ventilator support duration before ECMO weaning and VV ECMO mode. Clinicians should shorten the respiratory support duration for patients undergoing ECMO to prevent NP.
机译：目的我们旨在研究体外膜氧合（ECMO）期间医院肺炎（NP）的危险因素及预后。方法我们回顾性分析了2013年1月至2019年8月在南京医科大学附属杭州医院接受了ECMO的患者数据。主要结果是生存到排放率。结果六十九名接受ECMO的患者注册，中位年龄42岁和26名（37.7％）妇女; 14（20.3％）患者开发了NP。 NP发病率为24.7 / 1000 ECMO天。 NP患者接受静脉静脉（VV）ECMO的比例较高（50％vs.7.3％）; ECMO支撑持续时间（276与140小时），较长的呼吸机支撑持续时间（14.5与6天），较低的ECMO断奶成功率（50.0％vs.8.8％），降低生存到排放率降低（比没有NP的患者，28.6％vs.7％）。多变量分析显示了ECMO期间预测NP的独立风险因素是ECMO断奶前的呼吸机支撑持续时间（差距[或]？=？1.288; 95％置信区间[CI]：1.111-1.494）和VV ECMO模式（或？=？ 10.970; 95％CI：1.758-68.467）。结论ECMO期间NP与ECMO断奶和VV ECMO模式之前的呼吸机支撑持续时间有关。临床医生应缩短患有ECMO以防止NP的患者的呼吸支持持续时间。

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