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首页> 外文期刊>Journal of King Saud University >Cardioprotective molecular mechanism of syringic acid against isoproterenol induced post- myocardial toxicity in male albino wistar rats
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Cardioprotective molecular mechanism of syringic acid against isoproterenol induced post- myocardial toxicity in male albino wistar rats

机译：红外酸乙酸的心肌保护分子机制诱导雄性白醇类Wistar大鼠心肌毒性

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BackgroundSyringic acid (SA) is a natural phenolic compound and act as anti-diabetic, anti-cancer, anti-inflammatory agents. In our current research, investigation was carried out on the effect of SA on post conditioning on isoproterenol (ISO) induced myocardial injury in wistar rats.MethodsMale albino wistar rats were administered with ISO (30?mg/kg bw) to second, third and fourth group rats on 1st and 2nd days (with a 24?h interval) of experimental period. SA and metoprolol were orally given immediately after the second dose of ISO to second and fourth group of rats respectively. Myocardial damage was assessed by estimating the cardiac marker enzymes such as creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) and gamma glutamyl transferase (GGT), anti-oxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT), inflammatory markers such as nuclear factor-kappa B (NF-kB), tumor necrosis factor-α (TNF-α) and high sensitivity-C reactive protein (hs-CRP) along with body and heart weights. Transmission electron microscopy (TEM) was utilized to find any ultra-structural alterations in the heart tissues.ResultsCK-MB, LDH and GGT levels and hs-CRP levels were found to be increased in serum while decreased in hearts of ISO group of rats. SOD and CAT were found to be decreased significantly while NF-kB and TNF-α expression levels were significantly increased in heart tissues of ISO administered rats. Body weights were decreased significantly and heart weights were increased significantly in ISO group of rats. TEM study showed alterations in ISO group hearts. Post-treatment with SA significantly recovered myocardial damage caused by ISO administration.ConclusionBy counteracting with the above mentioned effects of ISO, our natural compound, SA exhibited recovery of myocardial damage caused by ISO administration in wistar rats. This is the first report revealing the cardioprotective activity of SA in post-myocardial infarction in rats.
机译：背景氧化酸（SA）是天然酚类化合物，并充当抗糖尿病，抗癌，抗炎剂。在我们目前的研究中，对SA对异丙醇（ISO）诱导的Wistar大鼠心肌损伤的调查进行了调查..在Wistar Rats中的心肌损伤。用ISO（30？Mg / kg BW）给予ISO（30？Mg / kg BW）施用第二，第三个和第四组大鼠在第1和第2天（具有24Ωh间隔）的实验期。在第二剂ISO至二次和第四组大鼠后立即口服SA和富含托洛尔。通过估计心脏标记酶如肌酸激酶-MB（CK-MB），乳酸脱氢酶（LDH）和γ谷氨酸转移酶（GGT），抗氧化酶如超氧化物歧化酶（SOD）和过氧化氢酶（猫）来评估心肌损伤），诸如核因子-κB（NF-KB），肿瘤坏死因子-α（TNF-α）和高灵敏度-C反应性蛋白（HS-CRP）等炎症标志物以及体内和心脏重量。利用透射电子显微镜（TEM）来查找心脏组织中的任何超结构改变。血清中发现血清中的血清中的LDH和GGT水平和HS-CRP水平增加，而ISO小鼠的心脏降低。发现SOD和猫显着下降，而ISO施用大鼠的心脏组织中NF-KB和TNF-α表达水平显着增加。体重显着下降，ISO组大鼠中的心脏重量显着增加。 TEM研究表明ISO集团心中的改变。随着SA的治疗显着回收了ISO施用引起的心肌损伤。结论，抵消了上述ISO，我们的天然化合物，SA的疗效，表现出由Wistar大鼠ISO给药造成的心肌损伤的恢复。这是第一份报告揭示大鼠后心肌梗死中SA的心脏保护活性。

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