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首页> 外文期刊>Journal of King Saud University >Synthesis, structural characterization of silver(I)-NHC complexes and their antimicrobial, antioxidant and antitumor activities
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Synthesis, structural characterization of silver(I)-NHC complexes and their antimicrobial, antioxidant and antitumor activities

机译：银（I）-NHC复合物的合成，结构表征及其抗微生物，抗氧化剂和抗肿瘤活性

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To prepare a novel series of silver (I) complexes, the interaction of benzimidazolium salts having their two nitrogen atoms substituted by bulky groups with Ag2O in DMF has been carried out. Their structures were characterized by elemental analyses,1H NMR,13C NMR and IR spectroscopy techniques. Further, the antibacterial properties of both the salts and their silver(I)-NHC complexes were tested against positive and negative bacteria using the agar dilution procedure. The results show that silver complexes are effective againstSalmonella Typhimurium,Listeria monocytogenes, andMicrococcus luteuswith moderate to high activity, and their minimum inhibitory concentrations ranging from 0.0024 to 1.25?mg/ml. Moreover, the antioxidant activity determination of these compounds were studied with the DPPH, and compared with (gallic acid “GA“and butylatedhydroxytoluene “BHT “). They exhibited significant antioxidant activities. In addition, the of benzimidazoles salts2a-jand silver-NHC complexes3a-jwere screened for their antitumor activity. The highest antitumor activity was observed for3eand3dComplexes and they exhibited IC50 values 6.85?μg/mL against MCF-7 and 10.75?μg/mL against T47D, respectively.
机译：为了制备新的一系列银（I）络合物，已经进行了将苯并咪唑鎓盐的相互作用，其具有在DMF中具有Ag2O的庞大基团取代的庞大原子。它们的结构的特征在于元素分析，1H NMR，13C NMR和IR光谱技术。此外，使用琼脂稀释程序对盐和它们的银（I）-NHC复合物的抗菌性能进行测试，并使用琼脂稀释程序测试正面和阴性细菌。结果表明，银络合物是有效的抵抗血小板，李斯特里亚单核细胞增生，雌激素，黄氏菌，中等至高活性，其最小抑制浓度范围为0.0024至1.25Ωmg/ ml。此外，用DPPH研究了这些化合物的抗氧化活性测定，与（Gallic酸“Ga”和丁基化羟基甲苯“BHT”相比）。它们表现出显着的抗氧化活性。此外，苯并咪唑盐Salts2a-jand Silver-NHC复合物3a-jwere筛选它们的抗肿瘤活性。观察到最高的抗肿瘤活性为3And3D3DPrec用，并且它们分别向MCF-7和10.75×μg/ ml显示出IC 50值6.85×μg/ mL，分别对抗T47D。

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