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首页> 外文期刊>Journal of Medical Sciences >The Influence of Age-Sex on the Pattern of Immunodepression Following Surgery
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The Influence of Age-Sex on the Pattern of Immunodepression Following Surgery

机译：年龄 - 性别对手术后免疫抑制模式的影响

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Present study was conducted to evaluate patients for the influence of age -sex on the pattern of modulation of selected immune parameters, following surgery. Male patients, of varying ages, without any underlying immune depression and needing minor to moderate dissection were recruited randomly into the study following informed consent. They were placed in each of two groups: group 1 (GRP1) = ages 0.1 to 12 years and group 2 (GRP2) = ages 13 to 50 years. Blood samples were obtained 1) immediate preoperatively and 2) immediate postoperatively in every case and assessed for T-cell count, lymphocyte viability, B-cell count, total leukocyte count, total lymphocyte count and percentage lymphocyte transformation. T-cell counts and percent lymphocyte transformation alone were significantly different postoperatively but not preoperatively for both groups (p=0.023 and 0.031, respectively). All other parameters were not. Postoperative values for T-cell counts and lymphocyte transformation were, however, lower than their corresponding preoperative levels. The results have shown that age-sex influences immune parameters such as T-cell population and function after, but not before, surgery suggesting the possible involvement of background gonadal neuroendocrinologic influences in the immune response to surgical stress.
机译：进行了本研究，以评估患者对手术后选定免疫参数调节模式的影响。几年龄患者的男性患者，没有任何潜在的免疫抑郁症，并且需要在知情同意时随机招募进入研究中的研究。它们被置于两组中的每一个：第1组（GRP1）=年龄0.1至12岁，第2组（GRP2）=年龄13至50岁。血液样品获得1）立即术前和2）在每种情况下立即立即进行，并评估T细胞计数，淋巴细胞活力，B细胞计数，总白细胞计数，总淋巴细胞计数和百淋巴细胞计数和百淋巴细胞计数和百分比淋巴细胞转化。单独的T细胞计数和单独的淋巴细胞转化百分比显着不同，但对于两组（P = 0.023和0.031分别）显着不同。所有其他参数都没有。然而，T细胞计数和淋巴细胞转化的术后值低于其相应的术前水平。结果表明，年龄 - 性别影响免疫参数如T细胞群体和功能，但不是之前，手术表明背景性腺神经病理学影响可能参与免疫反应对外科应激的影响。

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