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首页> 外文期刊>Journal of Neural Transplantation and Plasticity: Neural Plasticity >High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period
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High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period

机译：在5年期间，高剂量甘氨酸治疗难治性强迫症和身体疑难症病症

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This paper describes an individual who was diagnosed with obsessive-compulsive disorder (OCD) and body dysmorphic disorder (BDD) at age 17 when education was discontinued. By age 19, he was housebound without social contacts except for parents. Adequate trials of three selective serotonin reuptake inhibitors, two with atypical neuroleptics, were ineffective. Major exacerbations following ear infections involving Group Aβ-hemolytic streptococcus at ages 19 and 20 led to intravenous immune globulin therapy, which was also ineffective. At age 22, another severe exacerbation followed antibiotic treatment forH. pylori.This led to a hypothesis that postulates deficient signal transduction by the N-methyl-D-aspartate receptor (NMDAR). Treatment with glycine, an NMDAR coagonist, over 5 years led to robust reduction of OCD/BDD signs and symptoms except for partial relapses during treatment cessation. Education and social life were resumed and evidence suggests improved cognition. Our findings motivate further study of glycine treatment of OCD and BDD.
机译：本文介绍了在17岁时被诊断出患有强迫症（OCD）和身体疑似疾病（BDD）的个体，当时预防教育时。截至19岁，除了父母外，他没有社交联系人。三种选择性血清素再摄取抑制剂的充分试验，两种具有非典型神经抑制剂，无效。在19岁和20岁的Aβ-溶血链球菌涉及组β-溶血链球菌后的重大加剧导致静脉注射免疫球蛋白疗法，这也是无效的。在22岁时，另一种严重的加剧后呈抗生素治疗Forh。幽门螺杆菌导致了由N-甲基-D-天冬氨酸受体（NMDAR）消除缺陷的信号转导的假设。甘氨酸甘氨酸治疗，甘露甘达队，超过5年的导致肿块，减少了OCD / BDD症状和症状，除了在治疗停止期间部分复发。恢复教育和社会生活，证据表明认知改善。我们的研究结果促进了对OCD和BDD的甘氨酸治疗的进一步研究。

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