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首页> 外文期刊>Journal of Neural Transplantation and Plasticity: Neural Plasticity >Applications of Acupuncture Therapy in Modulating the Plasticity of Neurodegenerative Disease and Depression: Do MicroRNA and Neurotrophin BDNF Shed Light on the Underlying Mechanism?
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Applications of Acupuncture Therapy in Modulating the Plasticity of Neurodegenerative Disease and Depression: Do MicroRNA and Neurotrophin BDNF Shed Light on the Underlying Mechanism?

机译：针刺治疗在调节神经退行性疾病和抑郁症的可塑性中的应用：DO MicroRNA和神经营养蛋白BDNF在底层机制上的光线吗？

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As the global population ages, the incidence of neurodegenerative diseases has risen. Furthermore, it has been suggested that depression, especially in elderly people, may also be an indication of latent neurodegeneration. Stroke, Alzheimer’s disease (AD), and Parkinson’s disease (PD) are usually accompanied by depression. The urgent challenge is further enforced by psychiatric comorbid conditions, particularly the feeling of despair in these patients. Fortunately, as our understanding of the neurobiological substrates of maladies affecting the central nervous system (CNS) has increased, more therapeutic options and novel potential biological mechanisms have been presented: (1) Neurodegenerative diseases share some similarities in their pathological characteristics, including changes in neuron structure or function and neuronal plasticity. (2) MicroRNAs (miRNAs) are small noncoding RNAs that contribute to the pathogenesis of diverse neurological disease. (3) One ubiquitous neurotrophin, brain-derived neurotrophic factor (BDNF), is crucial for the development of the nervous system. Accumulating data have indicated that miRNAs not only are related to BDNF regulation but also can directly bind with the 3′-UTR of BDNF to regulate BDNF and participate in neuroplasticity. In this short review, we present evidence of shared biological substrates among stroke, AD, PD, and depression and summarize the possible influencing mechanisms of acupuncture on the neuroplasticity of these diseases. We discuss neuroplasticity underscored by the roles of miRNAs and BDNF, which might further reveal the potential biological mechanism of neurodegenerative diseases and depression by acupuncture.
机译：随着全球人口的年龄，神经退行性疾病的发病率已上升。此外，已经提出抑郁症，尤其是老年人，也可能是潜在神经变性的指示。中风，阿尔茨海默病（AD）和帕金森病（PD）通常伴有抑郁症。精神病合并条件进一步强迫紧急挑战，特别是这些患者中绝望的感觉。幸运的是，随着我们对影响中枢神经系统（CNS）的疾病的神经生物学底物的理解增加，已经提出了更多的治疗方法和新的潜在生物机制：（1）神经退行性疾病在其病理特征中存在一些相似之处，包括变化神经元结构或功能和神经元塑性。 （2）MicroRNA（miRNA）是小的非致rNA，有助于各种神经疾病的发病机制。 （3）一种普遍存在的神经营养蛋白，脑衍生的神经营养因子（BDNF），对于神经系统的发展至关重要。累积数据表明，MIRNA不仅与BDNF调节有关，而且可以直接与BDNF的3'-UTR直接结合，以调节BDNF并参与神经塑性性。在这近综述中，我们提出了中风，广告，Pd和抑郁症之间共同生物基质的证据，并总结了针灸可能影响这些疾病的神经塑性的影响。我们讨论MiRNA和BDNF的角色强调神经塑性，这可能进一步揭示针刺神经变性疾病和抑郁症的潜在生物机制。

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