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首页> 外文期刊>Journal of Molecular Biology Research >The Curative Effect of a Second Curettage in Low-Risk Gestational Trophoblastic Neoplasia
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The Curative Effect of a Second Curettage in Low-Risk Gestational Trophoblastic Neoplasia

机译：低风险妊娠期滋养细胞瘤形成中第二曲率的疗效

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Background: Gestational trophoblastic neoplasia (GTN), despite its widespread metastases, is a very common cancer in women that is curable. Although the GTN cases show a good response to chemotherapy, in an effort to reduce toxic drug exposure, the second curettage has been suggested for some patients. In the current study, we have aimed to compare the benefits of the second curettage in comparison with single-agent chemotherapy for low-risk GTN patients. Methods: This retrospective observational study was carried out on GTN patients admitted to the gynecology department of Imam Khomeini Hospital in Ahvaz. The demographic profile of all participants was extracted. Patients' hospitalization records were also extracted from the files. Patients with an endometrial thickness above 10 mm were treated with re-curettage. The hCG clearance time was estimated by the Kaplan Meier plot. Results: In the present study, 148 patients with low-risk GTN stage 1 were studied. The time required for -hCG clearance in patients undergoing re-curettage was significantly lower than the chemotherapy receiving group (7 months vs. 10 months, p <0.0001). More than 50% of patients treated by re- curettage without needing chemotherapy. Moreover, the other 50% cases needed chemotherapy the number of courses was significantly lower than those received single-agent chemotherapy alone (p <0.0001). The baseline -hCG levels were significantly lower in those who did not need chemotherapy (p = 0.012). -hCG resolution occurred more rapidly in patients undergoing re-curettage alone, while, those who received only chemotherapy had a longer duration for -hCG clearance. Conclusion: In general, the findings of this study showed that re-curettage could be used effectively in the treatment of GTN following molar pregnancy. This treatment reduces or eliminates the need for chemotherapy. Our findings also showed that the initial level of -hCG could be considered as a predictive factor in response to curettage.
机译：背景：妊娠期滋养细胞瘤形成（GTN），尽管其普及转移，是可治愈的女性中的一种非常常见的癌症。虽然GTN病例表现出对化疗的良好反应，但在努力减少毒性药物暴露时，已经为一些患者提出了第二种刮宫。在目前的研究中，我们旨在比较第二种曲线的益处与单药物化疗进行低风险的GTN患者。方法：对奥姆·霍梅尼医院妇科妇科妇科妇科患者进行的，对艾姆·霍梅尼医院的GTN患者进行了这项回顾性观察研究。提取所有参与者的人口概况。患者的住院记录也从文件中提取。用重新施用处理子宫内膜厚度的患者。 HCG清除时间由Kaplan Meier Plot估算。结果：在本研究中，研究了148例低风险GTN阶段1患者。接受重新施用的患者的-HCG间隙所需的时间明显低于化疗接受组（7个月，5个月，P <0.0001）。超过50％的患者通过再施用而不需要化疗。此外，其他50％案例所需化疗疗程的数量明显低于单独接受的单药化疗（P <0.0001）。在不需要化疗的人中，基线-HCG水平显着较低（P = 0.012）。 -HCG分辨率在接受重新施法的患者中，虽然只接受化疗的患者发生了更长的时间持续时间 - HCG间隙。结论：一般来说，该研究的结果表明，在摩尔妊娠后GTN的治疗中可以有效地使用重新施法。该处理减少或消除了化疗的需求。我们的研究结果还表明，初始水平的-HCG可以被认为是响应刮宫的预测因素。

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