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首页> 外文期刊>Journal of Nepal Paediatric Society >Weekly versus Daily Iron Supplementation for Preventing Iron deficiency Anaemia Amongst Children Between Six to 24 Months: A Randomised Control Trial
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Weekly versus Daily Iron Supplementation for Preventing Iron deficiency Anaemia Amongst Children Between Six to 24 Months: A Randomised Control Trial

机译：每日与每日铁补充用于预防六至24个月之间的儿童中的缺铁性贫血：随机控制试验

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Introduction: Iron deficiency anaemia is common in developing nations and starting iron supplementation from infancy is an important measure for its prevention. There is still not enough evidence, whether giving iron twice weekly as compared to daily, is enough to prevent the same. Methods: This open-labeled randomised control trial was conducted at a tertiary care facility over a period of 1.5 years. After informed consent from parents, a total of 125 non-anaemic healthy infants in age group six to 24 months; with birth weight 2500 grams, born singleton at term gestation and predominantly breastfed in the first six months of life; were randomised using computer generated sequence to two groups. Control group received daily elemental iron supplementation of 1 mg/kg/day and the intervention group received twice weekly 2 mg/kg/day. Haemoglobin, serum ferritin were measured at enrolment and at the end of 100 days. Primary outcome was anaemia defined as haemoglobin less than 11 mg/dl. Secondary outcome measures were weight gain, increase in length and occipito-frontal circumference. Results: Baseline characteristics were similar in the two groups. This study showed significantly higher mean haemoglobin (mg/dl) (mean ± SD 11.882 ± 0.3237, 11.683 ± 0.4264, p = 0.009) and mean serum ferritin (ng/ml) (mean ± SD 101.704 ± 23.0263, 62.149 ± 24.2079, p = 0.000) at end of 100 days in the control group than the intervention group. There was no difference in any of the secondary outcomes. Conclusions: Biweekly iron supplementation can also prevent iron deficiency anaemia in children between six to 24 months of age but daily is better in respect to the increase in haemoglobin.
机译：介绍：缺铁性贫血在发展中国家常见，起始铁的婴儿期是预防的重要措施。仍然没有足够的证据，与每日相比每周两次给予铁，足以防止相同。方法：该开放式随机控制试验在第三年内在第三次护理机构进行。在父母知情同意后，年龄组共有125名非贫血健康婴儿六至24个月;出生体重> 2500克，出生于妊娠期妊娠，主要是在生命的前六个月的母乳喂养;使用计算机生成的序列随机分配到两组。对照组接受每日元素铁补充1毫克/千克/天，干预组每周接受2毫克/千克/天。血红蛋白，血清铁蛋白在招生和100天结束时测量。主要结果是贫血，定义为血红蛋白小于11mg / dL。二次结果测量是体重增加，长度和枕形额圆周增加。结果：两组基线特性相似。该研究表现出明显高的平均血红蛋白（Mg / D1）（平均值±Sd 11.882±0.3237,11.683±0.4264，p = 0.009）和平均血清铁蛋白（Ng / ml）（平均值±Sd 101.704±23.0263,62.149±24.2079，p = 0.000）在对照组的100天结束时比干预组。任何二次结果都没有差异。结论：双周铁补充剂还可以防止儿童缺铁贫血在6至24个月之间，但每日更好地就血红蛋白的增加而言。

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