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首页> 外文期刊>Journal of Ophthalmology >Assessment of Ganglion Cell Complex and Peripapillary Retinal Nerve Fiber Layer Changes following Cataract Surgery in Patients with Pseudoexfoliation Glaucoma
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Assessment of Ganglion Cell Complex and Peripapillary Retinal Nerve Fiber Layer Changes following Cataract Surgery in Patients with Pseudoexfoliation Glaucoma

机译：伪炼金糖患者白内障手术后神经节细胞复合物和围毛绒视网膜神经纤维层的评估

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Purpose. To assess eye pressure, ganglion cell complex, and retinal nerve fiber layer changes following cataract surgery in patients with pseudoexfoliation glaucoma. Methods. Eighty-five patients with pseudoexfoliation glaucoma (PEXG) were included in the study. They were divided into two groups; the first group included patients with PEXG and cataract who underwent phacoemulsification (pseudophakic group; n?=?40 eyes). The second group included patients with PEXG without cataract (control group; n?=?45 eyes). Both groups were on antiglaucoma treatment. IOP changes after surgery and the ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer (pRNFL) thicknesses were evaluated in patients underwent cataract extraction surgery compared to controls that did not have cataract, nor underwent surgery. Both groups were followed up postoperatively for 18?months. Results. There was no difference in the mean age and glaucoma stage in both groups (P=0.242 and 0.70, respectively). In the pseudophakic group, the mean IOP significantly dropped from 20.43?±?0.90 to 17.00?±?2.75?mmHg at the end of the follow-up period (P≤0.001). Slight decrease (≈3?μm) was recorded in the mean GCC thickness of the pseudophakic patients from the baseline at the end of the follow-up period. This decrease was lower than that of the controls (≈5?μm). No significant pRNFL changes were recorded all over the postoperative visits (88.78?±?22.55?μm at 3?months, 88.67?±?23.14?μm at 6?months, 87.62?±?23.04?μm at 12?months, and 87.32?±?22.61?μm at 18?months) as compared to preoperative value (90.28?±?22.31?μm) with P=0.335, 0.387, 0.158, and 0.110, respectively, or controls (89.69?±?21.76?μm, 88.73?±?21.08?μm, 87.33?±?20.67?μm, and 87.23?±?20.54?μm with P=0.850, 0.990, 0.951, and 0.984). Conclusion. Phacoemulsification and IOL implantation may aid in managing pseudoexfoliation glaucoma by lowering IOP and slowing the rate of GCC and pRNFL losses over a short-term period.
机译：目的。在伪拔出青光眼患者的白内障手术后评估眼压，神经节细胞复合物和视网膜神经纤维层的变化。方法。研究中包含八十五名伪炼金糖（PEXG）患者。他们分为两组;第一个组包括患有Pexg和白内障的患者，他们接受过沉重乳化（假磷真菌; N？= 40只眼）。第二组包括没有白内障的PEXG患者（对照组; N？= 45只眼睛）。两组都在抗原瘤治疗。手术后的IOP变化和神经节细胞复合物（GCC）和Peripapillary视网膜神经纤维层（PRNFL）厚度被评估与没有白内障的对照，也不是没有接受手术的对照。两组术后术后术后18个月。结果。两组的平均年龄和青光眼阶段没有差异（P = 0.242和0.70）。在假磷酸盐群中，平均IOP从20.43α±0.90至17.00？±2.75？mmhg在后续期间（p≤0.001）。在后续期结束时，在基线的平均GCC厚度下记录略微减少（≈3≤μm）。这种减少低于对照（≈5≤μm）。在术后访问（88.78？±22.55？μm，在3个月，88.67±±22.55？±22.55Ω·±22.55？±23.14，87.62？±23.04Ω，87.62？μm在12？μm，87.32与P = 0.335,0.335,0.387,0.158和0.110的术前值（90.28〜±22.31μm）相比，或对照（89.69≤21.76Ω·μm， 88.73？±21.08？μm，87.33？±20.67？μm，87.23？±20.54Ω·μm，p = 0.850,0.990,0.951和0.984）。结论。 Phacoem乳化和IOL植入可以通过降低IOP和减慢短期时期的GCC和PRNFL损失来管理伪挑选青光眼。

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