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首页> 外文期刊>Journal of Pharmacy and Bioallied Sciences >Microbiological and Clinical evaluation of Neem gel and Chlorhexidine gel on Dental Plaque and Gingivitis in 20-30 Years Old Adults: A Randomized Parallel-Armed, Double-Blinded Controlled Trial
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Microbiological and Clinical evaluation of Neem gel and Chlorhexidine gel on Dental Plaque and Gingivitis in 20-30 Years Old Adults: A Randomized Parallel-Armed, Double-Blinded Controlled Trial

机译：20-30岁成人牙菌斑和牙龈炎对牙菌斑和牙龈炎的微生物和临床评价：随机平行，双盲控制试验

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The etiological relationship between the plaque and the gingival inflammation has been long established. The long-term use of chemical antiplaque agents may lead to side effects such as teeth staining and alteration of taste. Therefore, natural plant extracts with potential antibacterial and anti-inflammatory activity have been explored, which are equally effective and safe for long-term use.Objective:The aim of this study was to compare and evaluate effect of neem gel and chlorhexidine (CHX) gel on dental plaque, gingivitis, and bacterial count of Streptococcus mutans and Lactobacilli among 20–30-year-old school teachers in a city of western Maharashtra, over 90 days’ usage.Materials and Methods:A double-blind, parallel armed, controlled, randomized clinical study was conducted among 60 school teachers of 20–30 years’ age group for 90 days. The two study groups were as follows: Group A––2.5% neem gel (n = 30) and Group B––0.2% CHX gel (n = 30). The plaque scores were recorded by Plaque Index (Löe H. The gingival index, the plaque index and the retention index systems. J Periodontol 1967;38:610-6) and gingival scores by Gingival Index (Löe H, Silness J. Periodontal disease in pregnancy. Acta Odontol Scand 1963;21:533-51). Streptococcus mutans and Lactobacilli species count by conventional culture method was carried out at baseline, 30th day and 90thday. Considering P value <0.05 as statistically significant, intergroup comparison was performed using unpaired t test. One-way analysis of variance (ANOVA) test was used followed by Tukey’s post hoc test for intragroup comparison.Results:The mean plaque, gingival scores, and microbial count of S. mutans and Lactobacilli showed significant reduction at 30th and 90th day in neem gel group as well as CHX gel group (P < 0.05). None of the parameter showed any significant change at 30th and 90th day (P > 0.05) on intergroup comparison.Conclusion:The neem gel showed significant decrease in dental plaque, gingival inflammation, and microbial counts, which was comparable to CHX gel proving to be a good herbal alternative. No side effects were reported for use of neem gel over considered period of time.
机译：斑块与牙龈炎症之间的病因关系已延长。长期使用化学抗分试剂可能导致副作用，例如牙齿染色和味道的变化。因此，已经探讨了具有潜在抗菌和抗炎活动的天然植物提取物，其同样有效和长期使用。目的：本研究的目的是比较和评估Neem凝胶和氯己定的效果（CHX）在西马哈拉施特市20-30岁的学校教师中牙龈牙菌斑，牙龈炎和乳酸菌细菌数量的牙龈，牙龈炎和乳杆菌的细菌数，超过90天的使用。使用双盲，平行，武装，受访，随机临床研究是在20-30岁年龄组的60名学校教师中进行的90天。这两种研究组如下：A - 2.5％Neem凝胶（n = 30）和B组 - 0.2％CHX凝胶（n = 30）。斑块分数被斑块指数记录（LÖEH.牙龈指数，斑块指数和保留指数系统。J SURDONTOL 1967; 38：610-6）和牙龈指数的牙龈评分（LÖEH，SILNES J.牙周病在怀孕。Acta Odontol Scand 1963; 21：533-51）。通过常规培养方法的链球菌和乳杆菌物种计数在基线，第30天和第90天进行。考虑到P值<0.05，以统计学上显着，使用未配对的T检验进行依族组比较。使用单向分析差异（ANOVA）测试，然后使用Tukey的Hoc测试，对Intragroup比较。结果：S. mutans和乳酸杆菌的平均斑块，牙龈评分和微生物计数在Neem的第30和第90天显示出显着减少凝胶组以及CHX凝胶组（P <0.05）。没有一个参数在族组比较上显示了第30天和第90天（P> 0.05）的任何显着变化。结论：Neem Gel显示出牙菌斑，牙龈炎症和微生物计数的显着降低，与CHX凝胶证明是相当的良好的草药替代品。据报道，没有副作用在考虑一段时间内使用Neem Gel。

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