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首页> 外文期刊>Journal of Pharmacy and Bioallied Sciences >Detection of Salivary Alkaline Phosphatase Levels in Smokers, Diabetic Patients, Potentially Malignant Diseases and Oral Malignant Tumours
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Detection of Salivary Alkaline Phosphatase Levels in Smokers, Diabetic Patients, Potentially Malignant Diseases and Oral Malignant Tumours

机译：吸烟者，糖尿病患者，潜在恶性疾病和口腔恶性肿瘤的唾液碱性磷酸酶水平的检测

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Alkaline phosphatase (ALP) is present in human and plays a key role in intracellular destructive processes and cellular damage. It has bicarbonate and phosphate ions, which help in buffering against acids. ALP activity is affected by smoking, which changes pH in oral environment and has harmful effects. Thus, the evaluation of ALP activity of smokers and healthy nonsmoker along with patients who were diabetic, potentially malignant, and malignant was carried out in this study.Materials and Methods:The study took place between 2016 and 2017. A total of 150 smokers, non-smokers, and patients who were diabetic, potentially malignant, and malignant were included. Collection of unstimulated whole saliva was done from each participant, and salivary ALP levels were measured by spectrophotometric assay.Results:Mean salivary ALP levels were significantly higher in smokers compared to those in nonsmokers. Mean ALP levels were also increased in patients who were diabetic, potentially malignant, and malignant compared to those in controls.Conclusion:ALP levels were significantly higher among smokers when compared to a healthy control group. Oral tissue function and side effects among smokers can be evaluated by these salivary enzyme alterations, which can serve as biomarkers for the diagnosis of any disease process. These salivary alterations could potentially be used as biochemical markers for the evaluation and early diagnosis. The higher levels were also found in patients who were diabetic, potentially malignant, and malignant, and ALP levels may also be used as biomarkers for the evaluation of the disease process.
机译：碱性磷酸酶（ALP）存在于人体中，并在细胞内破坏性过程和细胞损伤中发挥关键作用。它具有碳酸氢盐和磷酸盐离子，有助于缓冲酸。 ALP活动受吸烟的影响，在口腔环境中改变pH值并具有有害影响。因此，在本研究中对吸烟者和健康Nonsmoker的ALP活性与患有糖尿病患者的患者进行评估。在本研究中进行了患者。关于2016年和2017年之间的研究发生在2016年至2017年之间。共有150名吸烟者，包括糖尿病，患有糖尿病，潜在恶性和恶性的患者。从每个参与者完成未经刺激的整个唾液的集合，通过分光光度法测定唾液ALP水平。结果：与非吸烟者相比，吸烟者的平均唾液ALP水平显着高。与对照组相比，糖尿病，潜在恶性和恶性的患者的平均ALP水平也增加。结论：与健康对照组相比，吸烟者中的ALP水平显着高得多。通过这些唾液酶改变可以评估吸烟者之间的口腔组织功能和副作用，可作为诊断任何疾病过程的生物标志物。这些唾液改变可能被用作评估和早期诊断的生物化学标志物。患有糖尿病，潜在恶性和恶性肿瘤的患者也发现了较高的水平，并且ALP水平也可用作评估疾病过程的生物标志物。

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