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首页> 外文期刊>Journal of Pharmacy and Bioallied Sciences >Histocompatibility of Novel Cycloaliphatic Comonomer in Heat-cured Denture Base Acrylic Resin: Histomorphometric Analysis in Rats
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Histocompatibility of Novel Cycloaliphatic Comonomer in Heat-cured Denture Base Acrylic Resin: Histomorphometric Analysis in Rats

机译：热固化义齿基丙烯酸树脂中新型脂环族族族共聚单体的组织相容性：大鼠组织畸形分析

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Prosthodontics is impossible without denture base resins. Allergic reactions to these resins are not uncommon, albeit favorable properties. Monomeric modifications are being done to improve the properties of the material. Tricyclodecane dimethanol diacrylate (TCDDMDA) monomer has been recently identified and experimented as a comonomer with methyl methacrylate (MMA).Aim:This study aimed to investigate the histocompatibility of TCDDMDA comonomer in polymerized resin at 10% and 20% (vol/vol) concentrations in rats by histomorphometric analysis.Materials and Methods:Twenty-four male Wistar rats were randomly divided into the following four groups: NP group (control; n = 6), with no palatal appliance, Groups P0, P10, and P20 were fixed with palatal appliances fabricated of 100% MMA, 10% TCDDMDA + 90% MMA, and 20% TCDDMDA + 80% MMA, respectively. Weights of the animals were recorded just before the appliance placement and after 14 days. The animals were sacrificed, and the palatal tissues were processed for histopathological analysis. Histomorphometric parameters assessed were total epithelial (ET), connective tissue (CT), and keratin layer (KT) thicknesses.Results:No significant difference was observed regarding body weight. Group P0 showed increased ET, CT, and KT when compared to other groups. Bonferroni multiple comparison tests showed a statistically significant difference between all the groups except between P10 and P20 for all the three morphometric parameters.Conclusion:Palatal appliances with TCDDMDA comonomer showed good histocompatibility in rats up to 20% (vol/vol) concentration.
机译：没有义肢碱树脂，不可能的假肢模糊物质是不可能的。对这些树脂的过敏反应并不罕见，尽管有利的性质。正在进行单体修饰以改善材料的性质。最近鉴定了三环二甲烷二甲烷二甲烷（TCDDMDA）单体作为具有甲基丙烯酸甲酯（MMA）的共聚单体进行实验：本研究旨在研究聚合树脂中TCDDMDA共聚单体在10％和20％（Vol / Vol）浓度下的组织相容性通过组织素质分析的大鼠。材料和方法：将二十四只雄性Wistar大鼠随机分为以下四组：NP组（对照; n = 6），没有腭器用具，组P0，P10和P20固定腭器具分别由100％MMA，10％TCDDMDA + 90％MMA和20％TCDDMDA + 80％MMA制成。在设备展示位置之前和14天后，将动物的重量记录在一起。处死动物，并加工腭组织进行组织病理学分析。评估的组织素质分离参数是总上皮（ET），结缔组织（CT）和角蛋白层（KT）厚度。结果：对体重没有显着差异。与其他组相比，组P0显示升高的ET，CT和Kt。 Bonferroni多个比较测试显示所有组之间的统计学上显着的差异，除了P10和P20之间的所有三种形态学参数。结论：具有TCDDMDA共聚单体的腭器具在大鼠中显示出高达20％（Vol / Vol）浓度的良好组织相容性。

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