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首页> 外文期刊>Journal of Pharmacy and Bioallied Sciences >Efficacy of Psidium guajava and Allium sativum Extracts as Antimicrobial Agents against Periodontal Pathogens
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Efficacy of Psidium guajava and Allium sativum Extracts as Antimicrobial Agents against Periodontal Pathogens

机译：Psidium guajava和Allium sativum提取物作为针对牙周病原体的抗微生物剂的疗效

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The accumulation and maturation of bacterial plaque at the gingival margin is widely recognized as the primary etiological factor in the development of chronic periodontitis. With the rise in bacterial resistance to antibiotics, there is considerable interest in the development of other classes of antimicrobials for the control of infection.Aim:The aim of this study was to evaluate the efficacy of Psidium guajava (guava) and Allium sativum (garlic) on Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans.Materials and Methods:Aqueous guava extract (AGvE), ethanolic guava extract (EGvE), aqueous garlic extract (AGE), and ethanolic garlic extract (EGE) were prepared. The inhibitory effects of these extracts for the periodontal pathogens were tested by agar well diffusion method. Minimal inhibitory concentration (MIC) of the aqueous and ethanol extracts of guava and garlic was determined by macrobroth dilution method. Minimum bactericidal concentration (MBC) was done to observe the bactericidal effect of the guava and garlic extracts against the organisms.Results:Of the AGE, 25, 50, and 75 μL showed 16, 20, and 25 mm zone of inhibition, respectively, on P. gingivalis. The AGE showed greater bacteriostatic activity against the P. gingivalis with MIC determined at 16.6 μL/mL. MIC determined for AGvE and EGvE was at 75 μL/mL concentration for P. gingivalis, whereas EGvE showed the activity at 75 μL/mL on P. gingivalis. MIC determined for AGvE was at 50 μL/mL, whereas MIC determined for EGvE was at 3.12 μL/mL for A. actinomycetemcomitans.Conclusion:P. guajava and A. sativum displayed a significant antibacterial effect. A. sativum was found to be most effective against P. gingivalis, whereas P. guajava showed the highest efficacy on A. actinomycetemcomitans.
机译：在牙龈边缘处的细菌斑块的积累和成熟被广泛认为是慢性牙周炎发育中的主要病程因素。随着对抗生素的细菌性抗性的增加，对对感染的其他类别的抗微生物的发展存在相当兴趣。该研究的目的是评估Psidium guajava（番石榴）和艾滋病ativum的疗效（大蒜）在卟啉单胞菌和聚合杆菌诱导术中。制备番石榴水溶液（agve），乙醇番石榴提取物（egVe），含水大蒜提取物（年龄）和乙醇蒜提取物（EGE）。通过琼脂孔扩散法测试这些提取物对牙周病原体的抑制作用。通过Macrobroth稀释方法测定番石榴和大蒜水溶液和乙醇提取物的最小抑制浓度（MIC）。进行最小杀菌浓度（MBC）以观察番石榴和大蒜提取物对生物的杀菌作用。结果：25,50和75μl分别显示16,20和25mm的抑制区，在P. Gingivalis。该年龄对P.Gingivianis的抑制活性较大，MIC在16.6μL/ mL处测定。对于agve和EGVE确定的MIC为P.Gingivalis的75μl/ ml浓度，而例如，在P.Gingivalis上展示了75μL/ ml的活性。测定的agve的MIC为50μl/ ml，而对于EGVE确定的MIC为3.12μl/ ml，对于AltinomycetemcoLens.Conclusion：p。卦杰瓦和A.Sativum显示出显着的抗菌效果。 A. Sativum被发现对P. Gingivalis最有效，而P.Guajava对A.肺部肌瘤的疗效最高。

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