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首页> 外文期刊>Journal of the International Society of Sports Nutrition >CYP1A2 genotype and acute effects of caffeine on resistance exercise, jumping, and sprinting performance
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CYP1A2 genotype and acute effects of caffeine on resistance exercise, jumping, and sprinting performance

机译：CYP1A2基因型和咖啡因对抗性运动，跳跃和冲刺性能的急性作用

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BACKGROUND:It has been suggested that polymorphisms within CYP1A2 impact inter-individual variation in the response to caffeine. The purpose of this study was to explore the acute effects of caffeine on resistance exercise, jumping, and sprinting performance in a sample of resistance-trained men, and to examine the influence of genetic variation of CYP1A2 (rs762551) on the individual variation in responses to caffeine ingestion.METHODS:Twenty-two men were included as participants (AA homozygotes n?=?13; C-allele carriers n?=?9) and were tested after the ingestion of caffeine (3?mg/kg of body mass) and a placebo. Exercise performance was assessed with the following outcomes: (a) movement velocity and power output in the bench press exercise with loads of 25, 50, 75, and 90% of one-repetition maximum (1RM); (b) quality and quantity of performed repetitions in the bench press exercise performed to muscular failure with 85% 1RM; (c) vertical jump height in a countermovement jump test; and (d) power output in a Wingate test.RESULTS:Compared to placebo, caffeine ingestion enhanced: (a) movement velocity and power output across all loads (effect size [ES]: 0.20-0.61; p???0.05 for all); (b) the quality and quantity of performed repetitions with 85% of 1RM (ES: 0.27-0.85; p???0.001 for all); (c) vertical jump height (ES: 0.15; p?=?0.017); and (d) power output in the Wingate test (ES: 0.33-0.44; p???0.05 for all). We did not find a significant genotype × caffeine interaction effect (p-values ranged from 0.094 to 0.994) in any of the analyzed performance outcomes.CONCLUSIONS:Resistance-trained men may experience acute improvements in resistance exercise, jumping, and sprinting performance following the ingestion of caffeine. The comparisons of the effects of caffeine on exercise performance between individuals with the AA genotype and AC/CC genotypes found no significant differences.TRIAL REGISTRATION:Australian New Zealand Clinical Trials Registry. ID: ACTRN12619000885190.
机译：背景：已经提出了CYP1A2内的多态性，在对咖啡因的反应中影响各种变化。本研究的目的是探讨咖啡因对抗性训练样本中抗性运动，跳跃和冲刺性能的急性作用，并检查CYP1A2（RS762551）遗传变异对响应的个体变异的影响咖啡因摄入。方法：22名男子被包括作为参与者（AA homozygotes n？= 13; c-等位基因载体n？=Δ9）并在摄入咖啡因后进行测试（3？mg / kg体重）和一个安慰剂。通过以下结果评估运动性能：（a）台凳中的移动速度和功率输出，载荷为25,50,75和90％的一次重复（1rm）; （b）在肌腱锻炼中对肌肉发育失败的肌肉发育失败进行的肌肉发育失败的质量和数量; （c）垂直跳跃高度在跳转跳转测试中; （d）电影检测中的功率输出。结果：与安慰剂相比，咖啡因摄取增强：（a）所有载荷的运动速度和功率输出（效果尺寸：0.0-0.61; p？

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