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首页> 外文期刊>Journal of Young Pharmacists >Analgesic Nephropathy due to Diclofenac in a 24-year-old Indian Male Patient: A Case Report
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Analgesic Nephropathy due to Diclofenac in a 24-year-old Indian Male Patient: A Case Report

机译：由于24岁的印度男性患者中的双氯芬饼镇痛肾病：案例报告

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摘要

Analgesics are commonly prescribed first line agent for the treatment of rheumatological disorders like rheumatoid arthritis and ankylosing spondylitis. Renal toxicities are known adverse reactions of analgesics, however, acute onset renal injury due to analgesics in rheumatological disorders is not currently known. Here we describe a case of a 24-yearold Indian male patient who was diagnosed with ankylosing spondylitis three years back and was prescribed tablet Diclofenac 150 mg in three divided doses per day. The patient presented with breathlessness, pedal edema and decreased urine output on 24th February 2019. The patient was diagnosed to have bilateral End Stage Renal Disease (ESRD) with small kidneys, pulmonary edema and left ventricular dysfunction using echocardiography. The patient was symptomatically treated and later transferred for renal transplant. Renal toxicity of analgesics is known but is usually reported after years of exposure. This case is first of the kind of occurrence of ESRD within three years of exposure. This case highlights the need for monitoring in patients who are prescribed analgesics for a long duration especially in patients of rheumatological disorders.
机译：镇痛药是通常规定的第一线代理，用于治疗类风湿性关节炎和强直性脊柱炎等风湿病。肾脏毒性是众所周知的镇痛药的不良反应，然而，目前急性发作引起的镇痛药引起的肾损伤尚不清楚。在这里，我们描述了一个24岁的印度男性患者，被诊断为脊柱炎三年，并在每天三分裂剂量中被规定的片剂双氯芬酸150毫克。患者患有呼吸困难，脚踏水肿和2019年2月24日尿量减少。患者被诊断为具有小肾脏，肺水肿和使用超声心动图的患者的双侧末期肾病（ESRD）。患者症状治疗，后来转移为肾移植。镇痛药的肾毒性是已知的，但经过多年的暴露，通常报告。这种情况首先发生在曝光三年内ESRD的类型。这种情况突出了在持续时间的镇痛药的患者中对患者进行监测的需要，尤其是风湿病患者。

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