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首页> 外文期刊>Journal of Translational Medicine >Patterns of tumor response in canine and feline cancer patients treated with electrochemotherapy: preclinical data for the standardization of this treatment in pets and humans
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Patterns of tumor response in canine and feline cancer patients treated with electrochemotherapy: preclinical data for the standardization of this treatment in pets and humans

机译：用电化学治疗犬和猫癌患者肿瘤反应模式：宠物和人类治疗标准化的临床前数据

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Electrochemotherapy (ECT) is a novel anticancer therapy that is currently being evaluated in human and pet cancer patients. ECT associates the administration of an anti-tumor agent to the delivery of trains of appropriate waveforms. The increased uptake of chemotherapy leads to apoptotic death of the neoplasm thus resulting in prolonged local control and extended survival. In this paper we describe the histological features of a broad array of spontaneous tumors of companion animals receiving pulse-mediated chemotherapy. Multivariate statistical analysis of the percentage of necrosis and apoptosis in the tumors before and after ECT treatment, shows that only a high percentage of necrosis and apoptosis after the ECT treatment were significantly correlated with longer survivals of the patients (p
机译：电化学疗法（ECT）是目前在人和宠物癌患者中评估的新型抗癌治疗。 ECT将抗肿瘤剂的给予给予适当波形的列车。增加的化疗摄取导致肿瘤的凋亡死亡，从而导致局部对照延长并延长存活。在本文中，我们描述了接受脉冲介导的化疗的伴侣动物的广泛自发肿瘤的组织学特征。在治疗前后肿瘤中坏死和细胞凋亡百分比的多变量统计分析，表明，在患者的较长患者的幸存下，只有高百分比的坏死和凋亡显着相关（p

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