...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Thoracic Disease >Cardiovascular risk of smoking and benefits of smoking cessation
【24h】

Cardiovascular risk of smoking and benefits of smoking cessation

机译：吸烟的心血管风险和吸烟的益处

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Smoking increases mortality from all causes and has a crucial role in atherosclerotic cardiovascular disease (ASCVD). Active smoking and secondhand smoke exposure determine more than 30% of coronary heart disease (CHD) mortality. The exact mechanisms of cardiovascular damages are not well known, but the detrimental effect of smoking on endothelial function has long been recognized. Smoking elicits oxidative processes, negatively affects platelet function, fibrinolysis, inflammation and vasomotor function; all these proatherogenic effects double the 10-year risk of fatal events in smokers compared to non smokers. An intriguing issue about smoking is the vulnerability of female gender. The mortality from cardiovascular diseases (CVDs) is higher in female than male smokers and female smokers show a 25% higher risk of developing CHD than men with the same exposure to tobacco smoke. This female vulnerability seems to be related to genes involved in thrombin signaling. The effects of smoking cessation have also been extensively studied. Cessation at an early age (40 years) has an impressive 90% reduction in the excess risk of death. In this review we report recent data about the causal link between smoking and CVDs and about the benefits of smoking cessation.
机译：吸烟增加了所有原因的死亡率，在动脉粥样硬化心血管疾病（ASCVD）中具有至关重要的作用。活跃的吸烟和二手烟暴露确定冠心病（CHD）死亡率的30％以上。心血管损伤的确切机制尚不熟知，但是在内皮功能上的不利影响已经识别。吸烟引发氧化过程，对血小板函数，纤维蛋白溶解，炎症和血管传神功能产生负面影响;与非吸烟者相比，所有这些后遗产效应都将10年的致命事件风险翻了一番。吸烟的一个有趣问题是女性性别的脆弱性。心血管疾病（CVDS）的死亡率比男性吸烟者和女性吸烟者均显示出比烟草烟雾相同暴露的男性患CHD的风险增加25％。这种女性脆弱性似乎与参与凝血酶信号传导的基因有关。吸烟戒烟的影响也得到了广泛研究。在休息时间（40岁）的戒烟令人印象深刻的90％，减少死亡风险过剩。在这篇综述中，我们报告了有关吸烟和CVDS之间的因果关系以及吸烟戒烟的好处的近期数据。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号