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首页> 外文期刊>BMC Cancer >The prognostic value of preoperative fibrinogen-to-prealbumin ratio and a novel FFC score in patients with resectable gastric cancer
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The prognostic value of preoperative fibrinogen-to-prealbumin ratio and a novel FFC score in patients with resectable gastric cancer

机译：可重置胃癌患者术前纤维蛋白原与前蛋白比率和新型FFC评分的预后价值

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BACKGROUND:Chronic inflammation is considered as a hallmark of gastric cancer (GC) and plays a critical role in GC progression and metastasis. This study aimed to explore the prognostic values of preoperative fibrinogen-to-prealbumin ratio (FPR), fibrinogen-to-albumin ratio (FAR), and novel FPR-FAR-CEA (FFC) score in patients with GC undergoing gastrectomy.METHODS:A total of 273 patients with resectable GC were included in this retrospective study. We performed Kaplan-Meier and Cox regression analyses to assess the prognostic role of preoperative FPR, FAR, and FFC score in patients with GC and analyze their relationships with clinicopathological features.RESULTS:Receiver operating characteristic curve (ROC) analysis revealed that the optimal cutoff values for FPR and FAR were 0.0145 and 0.0784, respectively. The FFC score had a higher area under the ROC curve than FAR and CEA. Elevated FPR (≥ 0.0145) and FAR (≥ 0.0784) were significantly associated with old age, large tumor size, tumor invasion depth, lymph nodes metastasis, advanced TNM stage, large Borrmann type, and anemia status. Kaplan-Meier analysis showed that high FPR, FAR, and FFC score were related to poor survival. Multivariate analyses indicated that FPR, FFC score, TNM stage, and tumor size were significant independent factors for survival.CONCLUSIONS:Preoperative FPR and FFC score could be used as prospective noninvasive prognostic biomarkers for resectable GC.
机译：背景：慢性炎症被认为是胃癌（GC）的标志，并在GC进展和转移中起着关键作用。本研究旨在探讨术前纤维蛋白原 - 预期比率（FPR），纤维蛋白酶对白蛋白比（FFC）和新型FPR-FAR-CEA（FFC）评分的预后值，患有GC患者的胃肠杆菌术治疗方法。方法：在这项回顾性研究中，共有273例可重症的GC患者。我们进行了Kaplan-Meier和Cox回归分析，以评估GC患者术前FPR，FFC评分的预后作用，并与临床病理特征分析它们的关系。结果：接收器操作特征曲线（ROC）分析显示最佳截止FPR的价值分别为0.0145和0.0784。 FFC评分在ROC曲线下具有比远和CEA的更高的区域。升高的FPR（≥0.0145）和远（≥0.0784）与老年，大肿瘤大小，肿瘤侵袭深度，淋巴结转移，先进的TNM阶段，大型Borrmann类型和贫血地位有显着相关。 Kaplan-Meier分析表明，FFC和FFC评分高的FPR与差的存活率有关。多变量分析表明，FPR，FFC评分，TNM阶段和肿瘤大小是存活率的显着独立因素。结论：术前FPR和FFC得分可用作可重症GC的前瞻性非侵入性预后生物标志物。

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