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首页> 外文期刊>International Journal of Molecular Sciences >CDKs in Sarcoma: Mediators of Disease and Emerging Therapeutic Targets
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CDKs in Sarcoma: Mediators of Disease and Emerging Therapeutic Targets

机译：肉瘤中的CDK：疾病和新兴治疗目标的介质

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摘要

Sarcomas represent one of the most challenging tumor types to treat due to their diverse nature and our incomplete understanding of their underlying biology. Recent work suggests cyclin-dependent kinase (CDK) pathway activation is a powerful driver of sarcomagenesis. CDK proteins participate in numerous cellular processes required for normal cell function, but their dysregulation is a hallmark of many pathologies including cancer. The contributions and significance of aberrant CDK activity to sarcoma development, however, is only partly understood. Here, we describe what is known about CDK-related alterations in the most common subtypes of sarcoma and highlight areas that warrant further investigation. As disruptions in CDK pathways appear in most, if not all, subtypes of sarcoma, we discuss the history and value of pharmacologically targeting CDKs to combat these tumors. The goals of this review are to (1) assess the prevalence and importance of CDK pathway alterations in sarcomas, (2) highlight the gap in knowledge for certain CDKs in these tumors, and (3) provide insight into studies focused on CDK inhibition for sarcoma treatment. Overall, growing evidence demonstrates a crucial role for activated CDKs in sarcoma development and as important targets for sarcoma therapy.
机译：由于他们多样化的性质和对其潜在的生物学的不完全理解，肉瘤代表最具挑战性的肿瘤类型之一。最近的工作表明，细胞周期蛋白依赖性激酶（CDK）途径激活是SARComagenesis的强大驱动因素。 CDK蛋白参与正常细胞功能所需的许多细胞工艺，但它们的失呼量是许多病态的标志，包括癌症。然而，异常CDK活动对肉瘤发展的贡献和意义仅部分地理解。在这里，我们描述了关于CDK相关的改变中所知的肉瘤中最常见的改变，并突出显示进一步调查的区域。由于CDK途中的中断出现在大多数情况下，如果不是全部，肉瘤的亚型，我们讨论了药理学靶向CDK的历史和价值，以对抗这些肿瘤。本综述的目标是（1）评估CDK途径改变在肉瘤中的患病率和重要性，（2）突出这些肿瘤中某些CDK的知识差距，（3）提供对专注于CDK抑制的研究的洞察力肉瘤治疗。总体而言，日益增长的证据表明了肉瘤发育中活化的CDK的关键作用以及作为肉瘤治疗的重要目标。

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