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首页> 外文期刊>International Journal of Molecular Sciences >LncRNAs in the Type I Interferon Antiviral Response
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LncRNAs in the Type I Interferon Antiviral Response

机译：I型Interferon抗病毒反应的LNCRNA

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摘要

The proper functioning of the immune system requires a robust control over a delicate equilibrium between an ineffective response and immune overactivation. Poor responses to viral insults may lead to chronic or overwhelming infection, whereas unrestrained activation can cause autoimmune diseases and cancer. Control over the magnitude and duration of the antiviral immune response is exerted by a finely tuned positive or negative regulation at the DNA, RNA, and protein level of members of the type I interferon (IFN) signaling pathways and on the expression and activity of antiviral and proinflammatory factors. As summarized in this review, committed research during the last decade has shown that several of these processes are exquisitely regulated by long non-coding RNAs (lncRNAs), transcripts with poor coding capacity, but highly versatile functions. After infection, viruses, and the antiviral response they trigger, deregulate the expression of a subset of specific lncRNAs that function to promote or repress viral replication by inactivating or potentiating the antiviral response, respectively. These IFN-related lncRNAs are also highly tissue- and cell-type-specific, rendering them as promising biomarkers or therapeutic candidates to modulate specific stages of the antiviral immune response with fewer adverse effects.
机译：免疫系统的正常功能需要在无效的反应和免疫过度激活之间对微小均衡的稳健控制。对病毒性侮辱的反应差可能导致慢性或压倒性的感染，而无拘无束的活化会导致自身免疫疾病和癌症。对抗病毒免疫应答的幅度和持续时间进行控制，通过DNA，RNA和I型干扰素（IFN）信号传导途径和抗病毒的表达和活性的细微调谐的阳性或阴性调节来施加抗病毒的正或阴性调节和促炎因子。如在本次审查中，在过去十年中的致力研究表明，这些过程中的几个过程由长期非编码RNA（LNCRNA），具有差的差的成绩单，但具有高通用功能的转录物。在感染，病毒和抗病毒反应它们触发后，通过分别灭活或增强抗病毒反应，张解特定LNCRNA的子集的表达，其通过灭活或增强抗病毒反应来促进或压制病毒复制。这些IFN相关的LNCRNA也是高度组织和细胞类型特异性的，使其作为有前途的生物标志物或治疗候选者，以调节抗病毒免疫应答的特定阶段与较少的不良反应。

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