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首页> 外文期刊>International Journal of Molecular Sciences >Comprehensive Analysis of Expression, Clinicopathological Association and Potential Prognostic Significance of RABs in Pancreatic Cancer
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Comprehensive Analysis of Expression, Clinicopathological Association and Potential Prognostic Significance of RABs in Pancreatic Cancer

机译：综合分析胰腺癌中RABs的表达，临床病理学结合与潜在预后意义

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RAB proteins (RABs) represent the largest subfamily of Ras-like small GTPases that regulate a wide variety of endosomal membrane transport pathways. Their aberrant expression has been demonstrated in various malignancies and implicated in pathogenesis. Using The Cancer Genome Atlas (TCGA) database, we analyzed the differential expression and clinicopathological association of RAB genes in pancreatic ductal adenocarcinoma (PDAC). Of the 62 RAB genes analyzed, five (RAB3A, RAB26, RAB25, RAB21, and RAB22A ) exhibited statistically significant upregulation, while five ( RAB6B, RAB8B, RABL2A, RABL2B, and RAB32 ) were downregulated in PDAC as compared to the normal pancreas. Racially disparate expression was also reported for RAB3A, RAB25, and RAB26 . However, no clear trend of altered expression was observed with increasing stage and grade, age, and gender of the patients. PDAC from occasional drinkers had significantly higher expression of RAB21 compared to daily or weekly drinkers, whereas RAB25 expression was significantly higher in social drinkers, compared to occasional ones. The expression of RABL2A was significantly reduced in PDAC from diabetic patients, whereas RAB26 was significantly lower in pancreatitis patients. More importantly, a significant association of high expression of RAB21, RAB22A, and RAB25 , and low expression of RAB6B, RABL2A, and RABL2B was observed with poorer survival of PC patients. Together, our study suggests potential diagnostic and prognostic significance of RABs in PDAC, warranting further investigations to define their functional and mechanistic significance.
机译：Rab蛋白（RAB）代表RAS样小GTP酶的最大亚家族，其调节各种内体膜输送途径。他们的异常表达已经在各种恶性肿瘤中证明并涉及发病机制。使用癌症基因组阿特拉斯（TCGA）数据库，我们分析了RAB基因在胰腺导管腺癌（PDAC）中的差异表达和临床病理学结合。在分析的62个RAB基因中，与正常胰腺相比，5（RAB3A，RAB26，RAB25，RAB21和RAB22A）表现出统计学显着的上调，而五个（RAB6B，RAB8B，Rabl2A，RaBl2b和Rab32）下调。 rab3a，rab25和rab26还报道了种族上不同的表达。然而，随着患者的阶段和等级，年龄和性别的增加，没有观察到改变表达的明显趋势。与日常或每周饮酒者相比，偶尔饮酒者的PDAC表达明显高，而紫外表达在社交饮酒者中显着高得多，而偶尔会有较高的表达。从糖尿病患者的PDAC中，Rable2a的表达显着降低，而胰腺炎患者的RAB26显着降低。更重要的是，用较差的PC患者存活率观察到Rab21，Rab22a和Rab25的高表达和低表达的显着关联，以及Rab6b，Rabl2a和Rabl2b的低表达。我们的研究在一起表明，RAB在PDAC中的潜在诊断和预后意义，需要进一步调查来确定其功能和机械意义。

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