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首页> 外文期刊>RSC Advances >Tailoring the morphological features of sol–gel synthesized mesoporous hydroxyapatite using fatty acids as an organic modifier
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Tailoring the morphological features of sol–gel synthesized mesoporous hydroxyapatite using fatty acids as an organic modifier

机译：使用脂肪酸作为有机改性剂来剪裁溶胶 - 凝胶合成的介孔羟基磷灰石的形态学特征

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Nowadays, owing to their large surface area, enhanced pore volume, increased porosity, and variable pore size, mesoporous materials, such as mesoporous silica and mesoporous carbon, have attracted significant attention in the areas of physical science and biomedical sciences. Due to their compositional and biological similarities to natural tissues, synthetic nanoscaled mesoporous hydroxyapatite (MPHA) nanoparticles possess good biocompatibility, bioactivity, and osteoconductivity and have recently expanded their applicability in a wide range of fields such as in tissue replacement, drug/gene delivery carriers, and biocompatible coatings. In this study, we defined a novel route to synthesize mesoporous hydroxyapatite nanoparticles by the sol–gel method in the presence of stearic acid (SA), a biocompatible medium chain fatty acid that would function as an organic modifier. The as-prepared HAP particles were subjected to structural, functional and morphological characterization. Mesopores in HAP were observed for samples synthesized at pH 11 by removing the organic template. The porosity of HAP was confirmed by the Brunauer–Emmett–Teller (BET) analysis. The apatite deposition phenomenon in simulated body fluid at pH 7.4 confirms their in vitro bioactivity, and based on the in vitro cytotoxicity examined using Vero cell cultures, the as-prepared HAP particles exhibit excellent cytocompatibility and cell viability as high as 83% at an extract concentration as low as 25%. Moreover, the loading and leaching behavior of the drug in mesoporous HAP was studied using methionine (MT), an essential amino acid. These results confirm that nano mesoporous hydroxyapatite loaded with MT can be a potential aspirant as a biomaterial in biomedical applications.
机译：如今，由于其大表面积，增强的孔隙体积，增加的孔隙率和可变孔径，介孔材料，如中孔二氧化硅和中孔碳，在物理科学和生物医学科学领域引起了显着的关注。由于它们的构成和生物相似性与天然组织，合成纳米级介氨酸羟基磷灰石（MPHA）纳米颗粒具有良好的生物相容性，生物活性和骨导电性，并且最近在各种场中扩展了它们的适用性，例如组织替代，药物/基因递送载体和生物相容性涂层。在这项研究中，我们定义了一种新的途径，通过溶胶 - 凝胶法在硬脂酸（SA）存在下通过溶胶 - 凝胶法合成介氨酸羟基磷灰石纳米颗粒，该生物相容性介质链脂肪酸将其作为有机改性剂。受制备的Hap颗粒进行结构，功能和形态学。通过除去有机模板，观察到在pH11合成的样品中观察到的中孔。 BAP的孔隙率由Brunauer-Emmett-Teller（BET）分析证实。在pH7.4的模拟体液中的磷灰石沉积现象证实了它们的体外生物活性，并且基于使用Vero细胞培养物检查的体外细胞毒性，所制备的Hap颗粒在提取物中表现出优异的细胞相容性和细胞活性高达83％浓度低至25％。此外，使用甲硫氨酸（MT），研究了必需氨基酸，研究了药物在中孔Hap中的装载和浸出行为。这些结果证实，纳米中孔羟基磷灰石负载，MT可以是生物医学应用中的生物材料的潜在吸引力。

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