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首页> 外文期刊>RSC Advances >Three dimensional coupled reaction–diffusion modeling of calcium and inositol 1,4,5-trisphosphate dynamics in cardiomyocytes
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Three dimensional coupled reaction–diffusion modeling of calcium and inositol 1,4,5-trisphosphate dynamics in cardiomyocytes

机译：心肌细胞中钙和肌醇1,4,5-三磷动力学的三维耦合反应扩散建模

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Nanoparticles have shown great promise in improving cancer treatment efficacy by changing the intracellular calcium level through activation of intracellular mechanisms. One of the mechanisms of the killing of the cancerous cell by a nanoparticle is through elevation of the intracellular calcium level. Evidence accumulated over the past decade indicates a pivotal role for the IP _(3) receptor mediated Ca ~(2+) release in the regulation of the cytosolic and the nuclear Ca ~(2+) signals. There have been various studies done suggesting the role of IP _(3) receptors (IP _(3) R) and IP _(3) production and degradation in cardiomyocytes. In the present work, we have proposed a three-dimensional unsteady-state mathematical model to describe the mechanism of cardiomyocytes which focuses on evaluation of various parameters that affect these coupled dynamics and elevate the cytosolic calcium concentration which can be helpful to search for novel therapies to cure these malignancies by targeting the complex calcium signaling process in cardiomyocytes. Our study suggests that there are other factors involved in this signaling which can increase the calcium level, which can help in finding treatment for cancer. The cytosolic calcium level may be controlled by IP _(3) signaling, leak , source influx of calcium ( σ ) and maximum production of IP _(3) ( V _(P) ). We believe that the proposed model suggests new insight into finding treatment for cancer in cardiomyocytes through elevation of the cytosolic Ca ~(2+) concentration by various parameters like leak , σ , V _(P) and especially by other complex cell signaling dynamics, namely IP _(3) dynamics.
机译：通过激活细胞内机制改变细胞内钙水平，纳米粒子对改善细胞内钙水平改善癌症治疗效果很高。纳米颗粒杀死癌细胞的一种机制是通过细胞内钙水平的升高。在过去十年中积累的证据表明IP _（3）受体介导的Ca〜（2+）释放在细胞溶质和核Ca〜（2+）信号中的释放的枢转作用。已经有各种研究表明IP _（3）受体（IP _（3）R）和IP _（3）在心肌细胞中产生和降解的作用。在本作本作中，我们提出了一种三维不稳定状态的数学模型，用于描述心肌细胞的机制，该模型侧重于评估影响这些耦合动力学的各种参数，并提高胞质钙浓度，这有助于寻找新的疗法通过在心肌细胞中靶向复杂的钙信号传导过程来治愈这些恶性肿瘤。我们的研究表明，这种信号有其他因素可以增加钙水平，这可以有助于寻找癌症的治疗。胞质钙水平可以通过IP _（3）信号传导，泄漏，源极流量（σ）和IP _（3）的最大产生来控制（v _（p））来控制。我们认为，拟议的模型表明，通过泄漏，σ，v _（p）等各种参数，尤其是通过其他复杂的细胞信号动态，通过各种参数升高，拟议的模型在心肌细胞中对心肌细胞的治疗方法进行了新的洞察力。即IP _（3）动态。

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