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Rapid screening and quantification of multi-class antibiotic pollutants in water using a planar waveguide immunosensor

机译：使用平面波导免疫传感器在水中进行多级抗生素污染物的快速筛选和定量

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Antibiotics are commonly used in livestock-related agriculture and aquaculture, but they also remain in water and potentially threaten human health. Immunosensors are attractive tools for the rapid detection of antibiotics in water due to their high sensitivity and low costs. However, the simultaneous detection of multi-class antibiotics remains a challenge due to the limited number of detection sites on the immunochip. Also, matrix effects hinder the practical application of these sensors. This paper presents a method for multi-class antibiotic detection in real water using a planar waveguide immunosensor (PWI). We integrate the screening and quantitive detection sites on the same immunochip, and a single screening detection site could detect multi-class antibiotics from the same family, increasing the detection types of analytes. In addition, to eliminate the matrix effects, we develop a testing buffer for real water detection, so that complex pretreatments of the samples can be omitted. Using our sensor and testing buffer, we detect 14 different antibiotics in real water. Lincomycin can be detected with a detection limit of 0.01 μg L ~(?1) , and 13 quinolones can be screened in a single assay. These results demonstrate that this planar waveguide immunosensor is capable of simultaneous screening and quantification of multi-class antibiotic pollutants and is expected to be applied for practical environmental monitoring.
机译：抗生素通常用于与畜牧业相关的农业和水产养殖，但它们也留在水中并可能威胁人类健康。免疫传感器是由于其高灵敏度和低成本而快速检测水中抗生素的吸引力。然而，由于免疫量上有限的检测位点，同时检测多级抗生素仍然是挑战。此外，矩阵效应阻碍了这些传感器的实际应用。本文介绍了使用平面波导免疫传感器（PWI）实际水中多级抗生素检测的方法。我们将筛选和定量检测位点集成在同一免疫筒上，单个筛查检测部位可以从同一家族中检测多级抗生素，增加检测类型的分析物。另外，为了消除矩阵效应，我们开发了真实水检测的测试缓冲液，因此可以省略样品的复杂预处理。使用我们的传感器和测试缓冲液，我们检测到真实水中的14种不同的抗生素。可以用0.01μgL〜（α1）的检测限检测LiNcomcin，并且可以在单个测定中筛选13个喹啉酮。这些结果表明，该平面波导免疫传感器能够同时筛选和定量多级抗生素污染物，预计将适用于实际环境监测。

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