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Mass spectrometry-based metabolomics in health and medical science: a systematic review

机译：基于质谱的卫生和医学科学代谢组：系统审查

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Metabolomics is the study of the investigation of small molecules derived from cellular and organism metabolism, which reflects the outcomes of the complex network of biochemical reactions in living systems. As the most recent member of the omics family, there has been notable progress in metabolomics in the last decade, mainly driven by the improvement in mass spectrometry (MS). MS-based metabolomic strategies in modern health and medical science studies provide innovative tools for novel diagnostic and prognostic approaches, as well as an augmented role in drug development, nutrition science, toxicology, and forensic science. In the present review, we not only introduce the application of MS-based metabolomics in the above fields, but also discuss the MS analysis technologies commonly used in metabolomics and the application of metabolomics in precision medicine, and further explore the challenges and perspectives of metabolomics in the field of health and medical science, which are expected to make a little contribution to the better development of metabolomics.
机译：代谢组学是研究衍生自细胞和生物代谢的小分子的研究，这反映了生物系统中的复杂生物化反应网络的结果。作为OMICS家族最近的成员，在过去十年中，代谢组织的研究进展显着，主要由质谱（MS）的改善驱动。现代卫生和医学研究中基于MS的代谢策略为新颖的诊断和预后方法提供了创新工具，以及在药物开发，营养科学，毒理学和法医学中的增强作用。在本综述中，我们不仅在上述领域介绍了基于MS的代谢组学的应用，而且还讨论了代谢组科常用的MS分析技术以及在精密药物中应用代谢物学，并进一步探索代谢组学的挑战和视角在健康和医学领域，预计将对代谢组学的更好发展做出贡献。

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