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首页> 外文期刊>RSC Advances >Sophora interrupta Bedd. root-derived flavonoids as prominent antiviral agents against Newcastle disease virus
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Sophora interrupta Bedd. root-derived flavonoids as prominent antiviral agents against Newcastle disease virus

机译：Sophora Irrentiona床上。根衍生的黄酮类黄酮作为针对新城疫病毒的突出抗病毒药物

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The discovery and development of novel antiviral drugs from natural sources is continuously increasing due to limitations of currently available drugs such as toxic side effects, drug residue risk factors, high costs, and poor therapeutic strategies. Also, there are very few known antiviral drugs that are effective against only specific viruses. Hence, the present study is intended to isolate and characterize potent antiviral compounds from the methanolic root extract of Sophora interrupta Bedd. against avian paramyxovirus, Newcastle disease virus (NDV) and to distinguish the molecular basis of antiviral compounds. The two isolated flavonoids, maackiain ( SR-1 ) and echinoisoflavanone ( SR-2 ) exhibited the best antiviral activities against NDV infection in chicken embryo fibroblast cell lines compared to the standard antiviral drug, Ribavirin. Further, the in vitro studies and quantitative PCR analysis suggests that these flavonoids inhibit the viral entry, replication, and transcription, which may be beneficial as a promising strategy for the treatment of viral infections. Besides, the molecular docking studies of SR-1 and SR-2 exhibited high binding affinities of ?7.6 and ?8.0 kcal mol ~(?1) , respectively, and marked interactions with the NDV surface glycoprotein, hemagglutinin neuraminidase (HN). Also, the in silico toxicity properties as well pharmacokinetic studies of isolates revealed them as pharmacologically potent antiviral compounds.
机译：由于目前可用药物如毒性副作用，药物残留危险因素，高成本和差的治疗策略，因此来自天然来源的新型抗病毒药物的发现和开发是不断增加的。此外，还有很少的已知抗病毒药物，其仅对特定病毒有效。因此，本研究旨在将有效的抗病毒化合物分离和表征来自Sophora Ircrecta床的甲醇根提取物。针对禽副宫病毒，新城疫病毒（NDV）并区分抗病毒剂的分子基础。与标准抗病毒药物，利巴韦林相比，两种分离的黄酮类化合物（SR-1）和Echinoisoflavanone（SR-2）表现出对鸡胚胚胎细胞系中NDV感染的最佳抗病毒活性。此外，体外研究和定量PCR分析表明这些黄酮类化合物抑制病毒进入，复制和转录，这可能是治疗病毒感染的有希望的策略。此外，Sr-1和Sr-2的分子对接研究分别表现出高结合亲和力的α.7.6和α.8.0kcalmol〜（α1），并标记与NDV表面糖蛋白，血凝素神经氨氨酸酶（HN）的相互作用。而且，由于分离株的药代动力学研究，硅基毒性研究表明，它们是药理学效率的抗病毒剂。

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