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首页> 外文期刊>RSC Advances >Hydrogen peroxide-mediated synthesis of 2,4-substituted quinazolines via one-pot three-component reactions under metal-free conditions
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Hydrogen peroxide-mediated synthesis of 2,4-substituted quinazolines via one-pot three-component reactions under metal-free conditions

机译：过氧化氢介导的2,4-取代的喹唑啉通过无金属条件下的三分组分反应合成

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摘要

An efficient metal-free synthesis of 2,4-substituted quinazolines via a hydrogen peroxide-mediated one-pot three-component reaction of 2-aminoaryl ketones, aldehydes, and ammonium acetate has been developed. The transformation proceeded readily under mild conditions in the presence of commercially available hydrogen peroxide. The significant advantages of this approach are (1) the readily available atom-efficient and green hydrogen peroxide as oxidant; (2) no transition metal catalyst is required; (3) mild reaction conditions; and (4) wide substrate scope. To the best of our knowledge, utilizing hydrogen peroxide as an atom-efficient and green oxidant for the synthesis of 2,4-substituted quinazolines has not previously been reported in the literature. This method is complementary to previous protocols for the synthesis of 2,4-substituted quinazolines.
机译：已经开发出通过过氧化氢介导的2-氨基芳基酮，醛和乙酸铵的过氧化氢1-罐三元组分反应的有效无金属喹唑啉。在可商购的过氧化氢的存在下，在温和条件下易于进行。这种方法的显着优点是（1）易于获得的原子效率和绿色过氧化氢作为氧化剂; （2）不需要过渡金属催化剂; （3）温和的反应条件; （4）宽基板范围。据我们所知，利用过氧化氢作为原子有效和绿色氧化剂，以先前没有在文献中报道2,4-取代的喹唑啉。该方法与先前的合成的2,4-取代的喹唑啉合成的协议互补。

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