Investigating the biosynthesis of Sch-642305 in the fungus Phomopsis sp. CMU-LMA

Francesco Trenti; Karen E. Lebe; Emilie Adelin; Jamal Ouazzani; Carsten Schotte; Russell J. Cox

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Investigating the biosynthesis of Sch-642305 in the fungus Phomopsis sp. CMU-LMA

机译：研究真菌Phomopsis SP中SCH-642305的生物合成。 CMU-LMA

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Sch-642305 is an unusual bicyclic 10-membered macrolide produced by the filamentous fungus Phomopsis sp. CMU-LMA for which no biosynthetic evidence exists. Here, we generate a draft genome sequence of the producing organism and discover the biosynthetic gene cluster responsible for formation of Sch-642305. Targeted gene disruptions together with reconstitution of the pathway in the heterologous host Aspergillus oryzae dissect key chemical steps and shed light on a series of oxidoreductions occuring in the pathway.

机译：SCH-642305是由丝状真菌Phomopsis SP产生的不寻常的双环10-元胶片。没有生物合成证据的CMU-LMA。在这里，我们生成产生的生物体的基因组序列草案，并发现负责形成Sch-642305的生物合成基因簇。靶向基因破坏与异源宿主曲霉属植物的途径中的重构混合在途径中发生的一系列氧化指令上的关键化学步骤和脱光。

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《RSC Advances》 |2020年第46期|共8页
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Francesco Trenti; Karen E. Lebe; Emilie Adelin; Jamal Ouazzani; Carsten Schotte; Russell J. Cox;
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1. Investigating the biosynthesis of Sch-642305 in the fungusPhomopsissp. CMU-LMA [J] . Trenti Francesco, Lebe Karen E., Adelin Emilie, RSC Advances . 2020,第46期

机译：研究真菌骨科的SCH-642305的生物合成。 CMU-LMA
2. Isolation, structure elucidation and biological activity of metabolites from Sch-642305-producing endophytic fungus Phomopsis sp. CMU-LMA [J] . Emilie Adelin, Claudine Servy, Sylvie Cortial, Phytochemistry . 2011,第18期

机译：产Sch-642305的内生真菌Phomopsis sp。的代谢产物的分离，结构解析和生物学活性。 CMU-LMA
3. Absolute structure, biosynthesis, and anti-microtubule activity of phomopsidin, isolated from a marine-derived fungus Phomopsis sp. [J] . Kobayashi H., Meguro S., Yoshimoto T., Tetrahedron . 2003,第4期

机译：从海洋衍生真菌Phomopsis sp。分离得到的phomopsidin的绝对结构，生物合成和抗微管活性。
4. Microbia! hydroxylation of progesterone with Phomopsis sp. [C] . Gang Du, Tianchao Lai, Haiying Yang International Conference on Chemical Engineering and Advanced Materials . 2013

机译：微生物！黄体酮与Phomopsis sp的羟基化。
5. The application of real -time PCR to investigate the effect of the arbuscular mycorrhizal fungus Glomus intraradices on the plant pathogen Fusarium solani f. sp. phaseoli. [D] . Filion, Martin. 2003

机译：实时PCR技术在研究丛枝菌根真菌Glomus intraradices对植物病原枯萎病镰刀菌的影响。 sp。菜豆。
6. Strategies to enhance the production of pinoresinol and its glucosides by endophytic fungus (Phomopsis sp. XP-8) isolated from Tu-chung bark [O] . Jing Zhu, Lu Yan, Xiaoguang Xu, 2018

机译：从土中树皮中分离的内生真菌（Phomopsis sp。XP-8）提高松油醇和葡萄糖苷生产的策略
7. Retraction of “Absolute Stereostructures and Biogenetic Relationships of Phomopsols A and B, Including the First Axially Chiral Polyketide-Derived Alkaloid, from the Mangrove Endophytic Fungus Phomopsis sp. xy21” [O] . Wan-Shan Li, Han-Bo Hu, Zhong-Hui Huang, 2019

机译：从红树林内生真菌Fhomopsis Sp中缩回“Phomopsols A和B的绝对立体α和B和B的生物关系，包括第一轴向手性聚酮衍生的生物碱。 XY21“
8. Biochemical Investigations of the Host-Parasite Relationship of Mosquitos and the Parasite Fungus 'Lagenidium sp.'. [R] . Domnas, A. J. 1974

机译：蚊子与寄生真菌'Lagenidium sp。'宿主 - 寄生虫关系的生化研究。

Investigating the biosynthesis of Sch-642305 in the fungus Phomopsis sp. CMU-LMA

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