Investigating the biosynthesis of Sch-642305 in the fungusPhomopsissp. CMU-LMA

Trenti Francesco; Lebe Karen E.; Adelin Emilie; Ouazzani Jamal; Schotte Carsten; Cox Russell J.

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Investigating the biosynthesis of Sch-642305 in the fungusPhomopsissp. CMU-LMA

机译：研究真菌骨科的SCH-642305的生物合成。 CMU-LMA

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Sch-642305 is an unusual bicyclic 10-membered macrolide produced by the filamentous fungusPhomopsissp. CMU-LMA for which no biosynthetic evidence exists. Here, we generate a draft genome sequence of the producing organism and discover the biosynthetic gene cluster responsible for formation of Sch-642305. Targeted gene disruptions together with reconstitution of the pathway in the heterologous hostAspergillus oryzaedissect key chemical steps and shed light on a series of oxidoreductions occuring in the pathway.

机译：SCH-642305是一种由丝状真菌骨折产生的不寻常的双环10-元胶片。没有生物合成证据的CMU-LMA。在这里，我们生成产生的生物体的基因组序列草案，并发现负责形成Sch-642305的生物合成基因簇。靶向基因在异源Hostaspergillus oryzaEdissect关键化学步骤中的途径中的重构以及在途径中发生的一系列氧化氧化术中的脱光。

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《RSC Advances》 |2020年第46期|共8页
作者
Trenti Francesco; Lebe Karen E.; Adelin Emilie; Ouazzani Jamal; Schotte Carsten; Cox Russell J.;
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Leibniz Univ Hannover Inst Organ Chem Schneiderberg 38 D-30167 Hannover Germany;

Leibniz Univ Hannover Inst Organ Chem Schneiderberg 38 D-30167 Hannover Germany;

CNRS Inst Chim Subst Nat ICSN Gif Sur Yvette France;

CNRS Inst Chim Subst Nat ICSN Gif Sur Yvette France;

Leibniz Univ Hannover Inst Organ Chem Schneiderberg 38 D-30167 Hannover Germany;

Leibniz Univ Hannover Inst Organ Chem Schneiderberg 38 D-30167 Hannover Germany;

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正文语种 eng
中图分类化学;
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机译：研究真菌骨科的SCH-642305的生物合成。 CMU-LMA
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Investigating the biosynthesis of Sch-642305 in the fungusPhomopsissp. CMU-LMA

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