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A novel approach for obtaining α,β-diaminophosphonates bearing structurally diverse side chains and their interactions with transition metal ions studied by ITC

机译:获得α,β-二胺磷酸盐轴承结构各种侧链的新方法及其与ITC研究过渡金属离子的相互作用

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摘要

Aminophosphonates are an important group of building blocks in medicinal and pharmaceutical chemistry. Novel representatives of this class of compounds containing nontypical side chains are still needed. The aza-Michael-type addition of amines to phosphonodehydroalanine derivatives provides a simple and effective approach for synthesizing N ′-substituted α,β-diaminoethylphosphonates and thus affords general access to aminophosphonates bearing structurally diverse side chains. Thermodynamic analysis of the chosen aminophosphonates at physiological pH proves that they serve as potent chelators for copper( II ) ions and moderate chelators for nickel( II ) ions.
机译:氨基膦酸盐是药用和药物化学中的重要组建块。仍然需要这类含有非典型侧链的这类化合物的新颖代表。 AZA-Michael型向磷酸二羟氢胺的胺添加提供了一种简单有效的方法,用于合成N'-取代的α,β-二氨基乙基膦酸盐,因此提供了一般性进入含有结构各种侧链的氨基膦酸盐。在生理pH下对所选氨基膦酸盐的热力学分析证明,它们用作铜(II)离子和中等螯合剂的有效螯合剂,用于镍(II)离子。

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