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首页> 外文期刊>RSC Advances >Essential oil loaded pectin/chitosan nanoparticles preparation and optimization via Box–Behnken design against MCF-7 breast cancer cell lines
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Essential oil loaded pectin/chitosan nanoparticles preparation and optimization via Box–Behnken design against MCF-7 breast cancer cell lines

机译：精油负载果胶/壳聚糖纳米粒子通过Box-Behnken设计对阵MCF-7乳腺癌细胞系的制备和优化

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摘要

In the continuous search for effective cancer treatments, we here report a novel anticancer nanoparticulate system composed of jasmine oil (JO), an essential oil with proven anticancer activity and pectin/chitosan composite nanoparticles (Pec/CS NPs) as encapsulating materials to overcome JO's solubility and sensitivity problems using a green ionotropic gelation method. Pec/CS/JO NPs were formulated using Box–Behnken design (BBD) to estimate the interactions and effects of studied formulation variables on particle size, zeta potential and encapsulation efficiency to develop an optimized Pec/CS nanoformulation. The nano-encapsulation system preserved the consistency of total phenolic contents in JO and amended its thermal stability by 1.64 fold. The antioxidant potency of JO was enhanced after encapsulation by 96.28%. Consequently, the cytotoxic activity of bare Pec/CS NPs, pure JO and encapsulated JO in Pec/CS NPs against (MCF-7) breast cancer cells and (L-929) normal cells was evaluated using MTT assay. Encapsulated JO was more potent than pure JO with ≈13 fold improvement in anticancer activity, whereas the cell viability of normal cells wasn't affected but was rather enhanced when treated with Pec/CS NPs.
机译：在持续搜索有效的癌症治疗中，我们在此报告了由茉莉花（jo），一种新的抗癌纳米颗粒系统，一种具有经过验证的抗癌活性和果胶/壳聚糖复合纳米粒子（PEC / CS NP）作为封装JO的抗蛋白酶采用绿色离子胶凝法的溶解度和敏感性问题。使用Box-Behnken设计（BBD）制定PEC / CS / JO NPS，以估算研究的配方变量对粒度，Zeta电位和封装效率的相互作用和效果，以开发优化的PEC / CS纳米造型。纳米封装系统保留了JO中总酚类内容物的一致性，并将其热稳定性置换为1.64倍。在封装后，Jo的抗氧化效力增强了96.28％。因此，使用MTT测定评估裸PEC / CS NPS，纯PEC / CS NPS，纯jo和包封的jE在pec / cs nps的乳腺癌细胞和（l-929）正常细胞中的乳腺癌。封装的jo比纯jo更有效，含有含有抗癌活性的≈13倍，而正常细胞的细胞活力没有受到影响，但在用pec / cs nps处理时被增强。

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