• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Molecularly imprinted polymeric coatings for sensitive and selective gravimetric detection of artemether
【24h】

Molecularly imprinted polymeric coatings for sensitive and selective gravimetric detection of artemether

机译：用于敏感和选择性重量检测的可溶剂的分子印迹聚合物涂层

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Monitoring antimalarial drugs is necessary for clinical assays, human health, and routine quality control practices in pharmaceutical industries. Herein, we present the development of sensor coatings based on molecularly imprinted polymers (MIPs) combined with quartz crystal microbalance (QCM) for sensitive and selective gravimetric detection of an antimalarial drug: artemether. The MIP coatings are synthesized by using artemether as the template in a poly(methacrylic acid- co -ethylene glycol dimethacrylate) matrix. Artemether-MIP and the non-imprinted polymer (NIP) control or reference layers are deposited on 10 MHz dual-electrode QCM by spin coating (187 ± 9 nm layer thickness after optimization). The coatings are characterized by FTIR spectroscopy and atomic force microscopy that reveal marked differences among the MIP and NIP. The MIP-QCM sensor exhibits high sensitivity (0.51 Hz ppm ~(?1) ) with sub-10 ppm detection and quantification limits. The MIP-QCM sensor also exhibits a 6-fold higher sensitivity compared to the NIP-QCM, and a dynamic working range of 30–100 ppm. The response time of MIP-QCM devices for a single cycle of analyte adsorption, signal saturation, and MIP regeneration is less than 2.5 min. The sensor also demonstrates selectivity factors of artemether-MIP of 2.2 and 4.1 compared to artemisinin and lumefantrine, respectively. Reversibility tests reveal less than 5% variation in sensor responses over three cycles of measurements at each tested concentration. The MIP-QCM showed lower detection limits than conventional HPLC-UV, and faster response time compared to HPLC-UV and liquid chromatography-mass spectrometry (LC-MS).
机译：监测抗疟药是制药行业临床测定，人体健康和常规质量控制实践所必需的。在此，我们基于分子印迹聚合物（MIPS）与石英晶体微稳态（QCM）组合的传感器涂层的开发，用于敏感和选择性重量检测抗疟药剂：蒿甲醚。通过在聚（甲基丙烯酸酰基二醇二甲基丙烯酸酯）基质中的模板中，通过使用蒿甲醚作为模板来合成MIP涂层。通过旋涂（优化后187±9nm层厚度）沉积在10MHz的双电极QCM上沉积Artemeter-MIP和非印记聚合物（NIP）对照或参考层。涂层的特征在于FTIR光谱和原子力显微镜，可透露壁带中显着的差异。 MIP-QCM传感器具有高灵敏度（0.51Hz PPM〜（α1）），具有SUB-10 PPM检测和量化限制。与NIP-QCM相比，MIP-QCM传感器也表现出6倍的灵敏度，并且动态工作范围为30-100ppm。 MIP-QCM器件用于单循环的分析物吸附，信号饱和度和MIP再生的响应时间小于2.5分钟。与青蒿素和Lumefantrine分别相比，传感器还示出了Artemet-MIP的选择性因子。可逆性试验显示在每个测试浓度下三个测量循环的传感器响应的少于5％。与HPLC-UV和液相色谱 - 质谱（LC-MS）相比，MIP-QCM显示比常规HPLC-UV的检测限，较快的响应时间。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号