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首页> 外文期刊>RSC Advances >An efficient one-pot catalyzed synthesis of 2,5-disubstituted-1,3,4-oxadiazoles and evaluation of their antimicrobial activities
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An efficient one-pot catalyzed synthesis of 2,5-disubstituted-1,3,4-oxadiazoles and evaluation of their antimicrobial activities

机译：有效的单罐催化合成2,5-二取代-1,3,4-二唑和其抗微生物活性的评价

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One-pot synthesis of 1,3,4-oxadiazole derivatives was achieved by treatment of 2-((4-(phenoxathiin-2-yl)phthalazin-1-yl)oxy)acetohydrazide with aromatic aldehydes in the presence of cerium( IV ) ammonium nitrate in dichloromethane. This facile method was confirmed by the cyclization–oxidation reaction of the corresponding hydrazone by cerium( IV ) ammonium nitrate to afford the same 1,3,4-oxadiazoles. Also, the reaction of 2-((4-(phenoxathiin-2-yl)phthalazin-1-yl)oxy)acetohydrazide with aromatic carboxylic acids in the presence of cerium( IV ) ammonium nitrate in polyethylene glycol afforded 1,3,4-oxadiazole derivatives. The structural formulae of all products were confirmed and characterized by elemental analyses and spectral data. Most of the synthesized products were evaluated for their antibacterial and antifungal activities and showed potent to weak activity.
机译：通过在铈（IV的存在下，通过用芳香族醛（（4-（苯基）-2-基）酞嗪-1-基）氧基酰肼来实现1,3,4-二氧唑衍生物的单壶合成。（IV ）硝酸铵在二氯甲烷中。通过铈（IV）硝酸铵通过相应的腙的环化氧化反应来证实该容纳方法，得到相同的1,3,4-恶二唑。此外，在聚乙二醇中的铈（IV）硝酸铵存在下，2 - （（4-（苯甲酰基-2-基）酞嗪-1-基）氧基酰肼与芳族羧酸的反应得到1,3,4 - 脱氧唑衍生物。通过元素分析和光谱数据确认所有产品的结构式和特征。评估大多数合成产物的抗菌和抗真菌活性，并表现出弱的活性。

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