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首页> 外文期刊>RSC Advances >Green synthesis of 1,4-benzodiazepines over La2O3 and La(OH)3 catalysts: possibility of Langmuir–Hinshelwood adsorption
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Green synthesis of 1,4-benzodiazepines over La2O3 and La(OH)3 catalysts: possibility of Langmuir–Hinshelwood adsorption

机译：La2O3和La（OH）3催化剂的1,4-苯二氮藻的绿色合成：Langmuir-Hinshelwood吸附的可能性

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摘要

Lanthanum oxide [La _(2) O _(3) ] and lanthanum hydroxide [La(OH) _(3) ] have been utilized as bases for the three-component reaction of aldehyde, dimedone and o -phenylenediamine for the synthesis of 1,4-benzodiazepine derivatives. The X-ray diffraction pattern shows pure phase formation of both catalysts. The basicity of La _(2) O _(3) and La(OH) _(3) was measured by CO _(2) -TPD (temperature programmed desorption) experiment. The measurements indicate the presence of basic sites that are useful for the reaction. Surface area measurements using Brunauer–Emmett–Teller (BET) reveal a low surface area for both the materials. TEM measurements indicate agglomerated particles with heterogeneous size distribution. The multicomponent reaction also proceeds smoothly in aqueous media as well as organic solvents. The heterogeneous catalyst was successfully recycled for 11 iterations without losing the catalytic activity. Several reactions were performed to understand the mechanism of the adsorption and the experiments suggest that the reaction may possibly proceeds by a Langmuir–Hinshelwood adsorption mechanism.
机译：氧化镧[LA _（2）O _（3）]和氢氧化物[LA（OH）_（3）]已被用作醛，DimEdone和O-苯二胺用于合成的三组分反应的基础1,4-苯二氮卓衍生物。 X射线衍射图案显示了两种催化剂的纯相形成。通过CO _（2）-TPD（温度编程解吸）实验测量LA _（2）O _（3）和LA（OH）和LA（OH）_（3）的碱度。测量结果表明存在对反应有用的基本位点。使用Brunauer-Emmett-Teller（Bet）的表面积测量显示了两种材料的低表面积。 TEM测量表示具有异质尺寸分布的附聚颗粒。多组分反应还在水性介质和有机溶剂中平稳地进行。在不失催化活性的情况下成功再循环非均相催化剂在11次迭代。进行几种反应以了解吸附的机制，实验表明反应可能通过Langmuir-hinshelwood吸附机制进行。

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