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首页> 外文期刊>RSC Advances >Synthesis of well-defined core–shell nanoparticles based on bifunctional poly(2-oxazoline) macromonomer surfactants and a microemulsion polymerization process
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Synthesis of well-defined core–shell nanoparticles based on bifunctional poly(2-oxazoline) macromonomer surfactants and a microemulsion polymerization process

机译：基于双官能聚（2-恶唑啉）大分子单体表面活性剂和微乳液聚合方法的合成良好定义的核 - 壳纳米粒子

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Particles in the sub-100 nm range have attracted widespread attention in the past few years due to their application in drug delivery and diagnostics. Here we describe the synthesis of two bifunctional, amphiphilic poly(2-oxazoline) macromonomers with multiple acrylate groups in their hydrophobic block and azide or primary amino end groups. The amphiphilic macromonomers were applied in a microemulsion polymerization to form well-defined core-crosslinked nanoparticles with surface functional azide or amine groups. Therefore, an amphiphilic poly(2-oxazoline) was prepared by cationic ring-opening polymerization of 2-methyl-2-oxazoline to form the hydrophilic block and a mixture of 2-heptyl-2-oxazoline and 2-(5-pentyl-[(1,2,3-triazol)-4-yl-methacrylat)]-oxazoline to form the hydrophobic block and was terminated with an azide moiety as end group. The introduction of multiple methacrylate groups into the poly(2-oxazoline) macromonomers serve as a stabilizer in the microemulsion process to covalently link the polymer to the particle core. Variable particle sizes of 20–75 nm have been prepared by encapsulating different amounts of 1,6-hexanedioldimethacrylate (HDDMA) to swell the micellar core before subsequent crosslinking takes place. Finally, particle surface functionalization was achieved by converting the terminal azide group via Staudinger-reaction to a primary amine group. Nanoparticles with surface primary amine groups were functionalized with folic acid (FA), a GRGDS-peptide derivative and fluorescein isothiocyanate (FITC) by simple amidation reaction (FA, RGD-peptide) or thiourea formation (FITC).
机译：由于其在药物递送和诊断中的应用，在过去几年中，粒子100nm范围内的颗粒引起了广泛的关注。在这里，我们描述了在其疏水嵌段和叠氮化物或伯氨基端基中具有多个丙烯酸酯基团的两种双官能的两亲（2-恶唑啉）大分子单体的合成。将两亲型大分子单体施用于微乳液聚合中，形成具有表面官能叠氮化物或胺基的明确定义的核交联纳米颗粒。因此，通过阳离子环开环聚合来制备两亲性聚（2-恶唑啉）2-甲基-2-恶唑啉，形成亲水性嵌段和2-Heptyl-2-恶唑啉和2-（5-戊基 - [（1,2,3-三唑）-4-基 - 甲基丙烯酸）] - 恶唑啉，形成疏水嵌段，并用叠氮部分作为末端基团终止。将多种甲基丙烯酸酯基团引入聚（2-恶唑啉）的大分子单体中用作微乳液过程中的稳定剂，以共价将聚合物与颗粒核心连接。通过包封不同量的1,6-己二氢二甲基丙烯酸酯（HDDMA）在发生后续交联之前，通过将不同量的1,6-己二烷二氢甲基丙烯酸酯（HDDMA）溶胀的可变粒径为20-75nm。最后，通过将末端叠氮化物基团转化为伯胺基团来实现颗粒表面官能化。通过简单的酰胺化反应（FA，RGD-肽）或硫脲形成（FITC），用叶酸（Fa），GRGDS-肽衍生物和荧光素异硫氰酸酯（FITC）用叶酸（FA），GRGDS-肽衍生物和荧光素官能团官能化。

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