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Bio-based polycarbonates derived from the neolignan honokiol

机译：生物基聚碳酸酯来自Neolignan Honokiol

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摘要

Honokiol, a highly functional phenolic- and alkenyl-containing neolignan natural product isolated from several Magnolia plant species, is an interesting bio-based resource, which is shown to be useful directly as a monomer for the rapid and scalable synthesis of poly(honokiol carbonate) (PHC). PHC was synthesized in one step from the natural product using condensation polymerization methods. Polymers of number average molecular weight ( M _(n) ) ranging from 10–55 kDa were obtained on gram scales in yields up to 80%. Thermal analysis demonstrated high thermal stability, with degradation temperatures in excess of ca. 450 °C. Mechanical testing of several PHC polymers indicated a generally increasing storage modulus with increasing M _(n) and a similar trend with T _(g) . With an interest toward cardiovascular applications, initial cytotoxicity and fluorescence cell imaging studies were conducted and showed no cytotoxicity toward coronary venular endothelial cells (CVECs), which proliferated on PHC thin films up to a month. Bulk PHC is a robust material, as it underwent slow hydrolytic degradation under basic conditions ( ca. 0.1% per day under 1 M NaOH _((aq)) ), and no observable degradation under acidic and neutral conditions, each at 37 °C over 130 days. These polycarbonates serve as potential specialty engineering- or bio-materials derived from a commercially-available natural product monomer.
机译：HONOKIOL，从几种玉兰植物物种中分离的含有高效酚类和含链烯基的Neolignan天然产物，是一种有趣的生物基资源，其被证明是直接用作快速和可扩展合成的单体（纯碳酸盐的单体）（phc）。使用缩合聚合方法将PHC从天然产物从天然产品中合成。在10-55kda的数均分子量（m _（n））的聚合物在克鳞片中获得高达80％的克鳞片。热分析显示出高热稳定性，具有过量的劣化温度。 450°C。几种PHC聚合物的机械测试表明了通常增加的储存模量随着M _（n）的增加和与T _（g）的类似趋势。由于涉及心血管应用，进行初始细胞毒性和荧光细胞成像研究，并向冠状动脉内皮细胞（CVEC）没有细胞毒性，其在PHC薄膜上增殖高达一个月。散装pHC是一种鲁棒材料，因为它在基本条件下进行了缓慢的水解降解（约1m，每天0.1％在1M NaOH _（（aq））下），并且在酸性和中性条件下没有可观察的降解，每种条件为37°C超过130天。这些聚碳酸酯用作衍生自市售天然产物单体的潜在专业工程或生物材料。

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