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Bio-based polycarbonates derived from the neolignan honokiol

机译：源自新木脂酚厚朴酚的生物基聚碳酸酯

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摘要

Honokiol, a highly functional phenolic-and alkenyl-containing neolignan natural product isolated from several Magnolia plant species, is an interesting bio-based resource, which is shown to be useful directly as a monomer for the rapid and scalable synthesis of poly(honokiol carbonate) (PHC). PHC was synthesized in one step from the natural product using condensation polymerization methods. Polymers of number average molecular weight (M-n) ranging from 10-55 kDa were obtained on gram scales in yields up to 80%. Thermal analysis demonstrated high thermal stability, with degradation temperatures in excess of ca. 450 degrees C. Mechanical testing of several PHC polymers indicated a generally increasing storage modulus with increasing M-n and a similar trend with T-g. With an interest toward cardiovascular applications, initial cytotoxicity and fluorescence cell imaging studies were conducted and showed no cytotoxicity toward coronary venular endothelial cells (CVECs), which proliferated on PHC thin films up to a month. Bulk PHC is a robust material, as it underwent slow hydrolytic degradation under basic conditions (ca. 0.1% per day under 1 M NaOH(aq)), and no observable degradation under acidic and neutral conditions, each at 37 degrees C over 130 days. These polycarbonates serve as potential specialty engineering-or bio-materials derived from a commercially-available natural product monomer.
机译：厚朴酚是一种有趣的生物基资源，是一种有趣的生物基资源，它是一种可快速，可扩展地合成聚厚朴酚碳酸酯的单体，它是一种有趣的生物基资源，它是一种功能强大的含酚和烯基的新木脂素天然产物。 ）（PHC）。使用缩聚法一步一步从天然产物合成PHC。以克为单位获得数均分子量（M-n）为10-55 kDa的聚合物，产率最高为80％。热分析显示出高的热稳定性，降解温度超过约3℃。 450摄氏度。几种PHC聚合物的机械测试表明，随着M-n的增加，储能模量总体上将增加，而T-g的趋势则相似。出于对心血管应用的兴趣，进行了初步的细胞毒性和荧光细胞成像研究，结果表明对在PHC薄膜上增殖长达一个月的冠状静脉内皮细胞（CVEC）没有细胞毒性。本体PHC是一种坚固的材料，因为它在碱性条件下（在1 M NaOH（aq）下每天约0.1％每天）经历缓慢的水解降解，并且在酸性和中性条件下（在37摄氏度下，在130天内每天都没有可观察到的降解） 。这些聚碳酸酯可作为潜在的特种工程或生物材料，衍生自商业上可得的天然产物单体。

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