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首页> 外文期刊>RSC Advances >Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-alt-maleic anhydride) mixtures for wound care applications
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Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-alt-maleic anhydride) mixtures for wound care applications

机译：基于高压灭菌聚（乙烯醇）的抗微生物水凝胶和伤口护理应用的聚（甲基乙烯基醚 - ALT-马来酸酐）混合物

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摘要

Novel antimicrobial hydrogels with good mechanical and physical properties were synthesized by autoclaving aqueous mixtures of poly(vinyl alcohol) and poly(methyl vinyl ether- alt -maleic anhydride). The structure of these materials was studied by infrared spectroscopy, scanning electron microscopy and solid state nuclear magnetic resonance. The swelling behavior, mechanical properties and adhesion of the hydrogels to porcine skin were evaluated. It was established that these hydrogels exhibited antimicrobial properties and inhibited bacteria growth against Staphylococcus aureus . The biocompatibility of the hydrogels was confirmed using an MTT assay (indirect cytotoxicity) and by monitoring cell proliferation in contact with the gels (direct cytotoxicity).
机译：通过高压灭菌的聚（乙烯醇）和聚（甲基乙烯基醚 - ALT-MALEIC酸酐）通过高压灭菌的水性混合物合成具有良好机械和物理性质的新型抗微生物水凝胶。通过红外光谱，扫描电子显微镜和固态核磁共振研究了这些材料的结构。评价了水凝胶对猪皮肤的溶胀行为，机械性能和粘附性。确定这些水凝胶表现出抗微生物性能并抑制含金黄色葡萄球菌的细菌生长。使用MTT测定（间接细胞毒性）确认水凝胶的生物相容性，并通过监测与凝胶接触的细胞增殖（直接细胞毒性）。

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