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首页> 外文期刊>RSC Advances >Fabrication of a novel electrochemical sensing platform based on a core–shell nano-structured/molecularly imprinted polymer for sensitive and selective determination of ephedrine
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Fabrication of a novel electrochemical sensing platform based on a core–shell nano-structured/molecularly imprinted polymer for sensitive and selective determination of ephedrine

机译：基于芯壳纳米结构/分子印迹聚合物的新型电化学传感平台的制造，敏感和选择性测定麻黄碱

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摘要

A simple methodology was used to develop a novel sensor based on a core–shell/molecularly imprinted polymer (MIP) for the determination of ephedrine. The Fe _(3) O _(4) @SiO _(2) @TiO _(2) -MIP nanocomposite with a well-defined core–shell structure was synthesized using a simple imprinting strategy. The morphology of the synthesized nanocomposite was observed by scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy and the properties of the sensor were examined by cyclic voltammetry and electrochemical impedance spectroscopy. The fabricated electrochemical sensor based on the Fe _(3) O _(4) @SiO _(2) @TiO _(2) -MIP nanocomposite exhibits great features such as a remarkably low detection limit of 0.0036 μmol L ~(?1) (3 S _(b) / m ), superb selectivity in discriminating ephedrine from its structural analogues and good anti-interference ability towards several co-existing substances. Also, it was used to detect the concentration of ephedrine in the linear range of 0.0090–2.8 μmol L ~(?1) . Moreover, the proposed method demonstrates excellent repeatability and stability, with a relative standard deviation (RSD) of less than 1.4% and 1.6%, respectively. Analysis of ephedrine in pharmaceutical dosage forms and biological fluids is successfully carried out without the assistance of complicated pretreatment. The Fe _(3) O _(4) @SiO _(2) @TiO _(2) -MIP nanocomposite presented here with admirable merits makes it a promising candidate for developing an electrochemical sensor device to perform routine analysis of ephedrine.
机译：使用简单的方法，用于基于核 - 壳/分子印迹聚合物（MIP）的新型传感器用于测定麻黄碱。使用简单的压印策略合成具有明确定义的核壳结构的FE _（3）O _（4）@TiO_（2）@tio_（2）-mip纳米复合材料。通过扫描电子显微镜观察合成纳米复合材料的形态，通过循环伏安法和电化学阻抗光谱检查傅立叶射线衍射，傅立叶衍射，傅立叶衍射红外光谱和传感器的性能。基于Fe _（3）O _（4）@sio_（2）@tio_（2）-mip纳米复合材料的制造电化学传感器表现出具有很大的特征，例如低检测限为0.0036μmoll〜（？1 ）（3 s _（b）/ m），在鉴别麻黄碱与其结构性类似物和良​​好的抗干扰能力方面的精湛选择性，朝向几种共同存在的物质。此外，它用于检测在0.0090-2.8μmol1〜（α1）的线性范围内麻黄碱的浓度。此外，所提出的方法分别显示出优异的重复性和稳定性，相对标准偏差（RSD）分别小于1.4％和1.6％。在药物剂型和生物流体中的异铬分析，在没有复杂预处理的辅助下成功进行了生物流体。 Fe _（3）o _（4）@sio_（2）@tio_（2）-mip in in-mip纳米复合材料，其具有令人允许的优点使其成为开发电化学传感器装置以执行麻黄碱的常规分析的有希望的候选者。

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