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Disposable (bio)chemical integrated optical waveguide sensors implemented on roll-to-roll produced platforms

机译：一次性（BIO）化学集成光波导传感器在滚动到卷产生的平台上实现

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To enable wide spread dissemination of sensors in cost-critical applications and resource poor settings, methods to implement sensor chips using low-cost materials and mass-manufacturing methods are developed. In this paper we demonstrate that disposable polymeric integrated Young interferometer (YI) sensor chips, implemented on roll-to-roll mass-manufactured waveguides, are applicable for analyte specific sensing of small molecules and for multi-analyte detection of biomolecules. For the chemical sensing of small molecules, a sensor chip was functionalized with a molecularly imprinted polymer (MIP). We demonstrate that the MIP receptor layer is compatible with a polymer-based evanescent wave sensor for direct refractive index sensing. For multi-analyte detection of biomolecules, antibody-based receptor layers were patterned by inkjet printing onto the sensor surface demonstrating the applicability of the method with integrated YI chips. Demonstration of the analyte specific chemical- and biosensing with disposable polymeric YI sensor chips opens new possibilities to implement low-cost (bio)chemical sensors.
机译：为了在成本关键的应用和资源差的设置中实现传感器的广泛传播传感器，开发了使用低成本材料和大规模制造方法实现传感器芯片的方法。在本文中，我们证明了在卷到卷材制造的波导上实施的一次性聚合物集成幼隙干涉仪（YI）传感器芯片适用于小分子的分析物特异性感测和用于生物分子的多分析物检测。对于小分子的化学感测，用分子印迹聚合物（MIP）官能化传感器芯片。我们证明MIP受体层与用于直接折射率感测的基于聚合物的渐逝波传感器兼容。对于生物分子的多分析物检测，通过喷墨印刷将基于抗体基受体层图案化到传感器表面上，证明了该方法与集成的易芯片的适用性。分析物特异性化学和生物传感器芯片的分析物和生物传感器的示范开辟了实现低成本（BIO）化学传感器的新可能性。

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