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Disposable (bio)chemical integrated optical waveguide sensors implemented on roll-to-roll produced platforms

机译:在卷对卷生产平台上实施的一次性(生物)化学集成光波导传感器

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摘要

To enable wide spread dissemination of sensors in cost-critical applications and resource poor settings, methods to implement sensor chips using low-cost materials and mass-manufacturing methods are developed. In this paper we demonstrate that disposable polymeric integrated Young interferometer (YI) sensor chips, implemented on roll-to-roll mass-manufactured waveguides, are applicable for analyte specific sensing of small molecules and for multi-analyte detection of biomolecules. For the chemical sensing of small molecules, a sensor chip was functionalized with a molecularly imprinted polymer (MIP). We demonstrate that the MIP receptor layer is compatible with a polymer-based evanescent wave sensor for direct refractive index sensing. For multi-analyte detection of biomolecules, antibody-based receptor layers were patterned by inkjet printing onto the sensor surface demonstrating the applicability of the method with integrated YI chips. Demonstration of the analyte specific chemical-and biosensing with disposable polymeric YI sensor chips opens new possibilities to implement low-cost (bio)chemical sensors.
机译:为了在成本关键型应用和资源匮乏的环境中广泛传播传感器,开发了使用低成本材料和批量制造方法来实现传感器芯片的方法。在本文中,我们证明了在卷对卷大批量制造的波导上实现的一次性聚合物集成式Young干涉仪(YI)传感器芯片可用于小分子的分析物特异性检测以及生物分子的多分析物检测。为了对小分子进行化学感测,传感器芯片通过分子印迹聚合物(MIP)进行了功能化。我们证明了MIP受体层与基于聚合物的e逝波传感器兼容,可用于直接折射率传感。为了对生物分子进行多分析物检测,将基于抗体的受体层通过喷墨印刷在传感器表面上进行了图案化,证明了该方法与集成YI芯片的适用性。一次性聚合YI传感器芯片对特定于分析物的化学和生物传感的演示,为实现低成本(生物)化学传感器提供了新的可能性。

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