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首页> 外文期刊>RSC Advances >Poly(glycidyl methacrylate)-functionalized magnetic nanoparticles as platforms for linking functionalities, bioentities and organocatalysts
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Poly(glycidyl methacrylate)-functionalized magnetic nanoparticles as platforms for linking functionalities, bioentities and organocatalysts

机译：聚（甲基丙烯酸缩水甘油酯） - 官能化磁性纳米粒子作为用于连接功能，生物强度和有机催化剂的平台

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New magnetic core shell nanoparticles were synthesized consisting of a magnetite core and a poly(glycidyl methacrylate) shell. Magnetite nanoparticles were first coated by bis(methacryloyloxyethoxy)phosphate as a reactive alkene-containing anchor followed by radical polymerization of glycidyl methacrylate. The poly(glycidyl methacrylate) coated MNPs represent versatile magnetic nano-platforms capable of linking various N-, S- and O-nucleophiles by opening the oxirane ring. In this way bioentities such as α-amino acids could be introduced directly or via first introducing a binucleophile followed by acylation (biotin) or thiol-ene click chemistry (cinchonine). Comprehensive high resolution XPS spectroscopy investigations were used as a major tool for analyzing the various types of magnetic nanoparticles. The results are attractive for application in biomedicine, organocatalysis and nanotechnology.
机译：合成新的磁芯壳纳米粒子，由磁铁矿核和聚（甲基丙烯酸缩水甘油酯）壳组成。首先通过双（甲基丙烯酰氧基乙氧基乙氧基）磷酸盐作为反应性烯烃的锚定涂覆磁铁矿纳米颗粒，然后是甲基丙烯酸缩水甘油酯的自由基聚合。聚（甲基丙烯酸缩水甘油酯）涂覆的MNP代表了能够通过打开氧化氧乙烷环连接各种N-，S-和O核试剂的通用磁性纳米平台。以这种方式，诸如α-氨基酸的生物能力可以直接或通过首先引入酰核酸，然后通过酰化（生物素）或硫醇 - 烯键点击化学（Cinchonine）。综合高分辨率XPS光谱研究用作分析各种类型的磁性纳米粒子的主要工具。结果对于生物医学，有机能分析和纳米技术的应用是有吸引力的。

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