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首页> 外文期刊>RSC Advances >Hyaluronic acid-coated poly(d,l-lactide) (PDLLA) nanofibers prepared by electrospinning and coating
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Hyaluronic acid-coated poly(d,l-lactide) (PDLLA) nanofibers prepared by electrospinning and coating

机译：通过静电纺丝和涂层制备的透明质酸涂覆的聚（D，L-丙交酯）（PDLLA）纳米纤维

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Hyaluronic acid nanofibers (HA/PDLLA) were prepared by coating electrospun poly( D , L -lactide) (PDLLA) with different concentrations of HA. Highest concentration of HA deposited onto PDLLA nanofibers (17% per weight) were obtained by coating with 0.3% (w/v) HA. Coating with 0.5% (w/v) and 0.1% (w/v) HA yielded a deposit of 3.8% and 3% per weight, respectively. All nanofibers were 300–400 nm in diameter and microscopically homogeneous in structure, with traces of HA clearly visible on the surface and in-between the fibers. Examination of the nanofibers with Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) revealed changes in the properties of the nanofibers when coated with 0.3% (w/v) HA. Release of HA from HA/PDLLA fibers were at a linear and constant rate. One possible application for HA/PDLLA is the coating of surfaces, such as medical implants, to prevent secondary microbial infections during recovery from surgery.
机译：通过用不同浓度的HA涂覆ElectromatOM聚（D，L-LACTADE）（PDLLA）来制备透明质酸纳米纤维（HA / PDLLA）。通过涂覆0.3％（w / v）ha，获得沉积在Pdlla纳米纤维上的HA的最高浓度HA（每重17％）。 0.5％（w / v）和0.1％（w / v）ha的涂层分别产生3.8％和每重量的3％沉积物。所有纳米纤维直径为300-400nm，结构中的显微镜均匀，在表面和纤维之间清晰可见的痕迹。用傅里叶变换红外（FTIR）光谱法，热重分析（TGA）和差示扫描量热法（DSC）的检查显示纳米纤维在涂覆0.3％（w / v）ha时的变化。从HA / PDLLA纤维释放HA以线性和恒定速率。对于HA / PDLLA的一种可能施用是表面的涂层，例如医疗植入物，以防止在手术中恢复期间的继发微生物感染。

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