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首页> 外文期刊>RSC Advances >A copolymer capsule with a magnetic core for hydrophilic or hydrophobic drug delivery via thermo-responsive stimuli or carrier biodegradation
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A copolymer capsule with a magnetic core for hydrophilic or hydrophobic drug delivery via thermo-responsive stimuli or carrier biodegradation

机译：具有磁芯的共聚物胶囊，用于通过热响应刺激或载体生物降解进行亲水性或疏水药物递送

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In this work, we report the successful preparation of a dual-responsive polymer microcapsule carrier with a magnetic core, Fe _(3) O _(4) @capsule nanoparticles, by cross-linked polymerization of N -isopropylacrylamide and acrylamide in the presence of N , N ′-bis(acryloyl)cystamine as a crosslinker. These novel drug carriers can undergo volume phase transition upon changing the environmental temperature or biodegradation of the polymer capsule by cleavage of the predesigned disulfide bonds within the crosslinker in the presence of glutathione (GSH) for hydrophilic or hydrophobic drug release. Herein, we take doxorubicin hydrochloride (DOX) as a hydrophilic drug model and curcumin as a hydrophobic drug model for investigating thermal responsiveness and biodegradation of magnetic polymer capsule carriers. Results indicate that DOX is released rapidly with thermal treatment and the release rate of DOX at PBS 5 is much faster than that at PBS 7.4. In addition, the release of water-insoluble drug curcumin is much faster with the assistance of GSH than without.
机译：在这项工作中，通过在存在下，通过在存在下，通过磁芯，通过交联聚合在存在下，通过交联聚合，通过交联聚合，通过磁芯（Fe _（3）O _（4））的交联聚合在存在下，通过交联聚合来报告双响应聚合物微胶囊载体。 N，N'-BIS（丙烯酰基）胱胺作为交联剂。这些新型药物载体在改变聚合物胶囊的环境温度或生物降解时可以通过在谷胱甘肽（GSH）存在中改变聚合物胶囊的环境温度或生物降解，以便亲水或疏水药物释放的谷胱甘肽（GSH）的存在下的预测二硫键。在此，我们服用盐酸胍（DOX）作为亲水药物模型和姜黄素作为疏水性药物模型，用于研究磁性聚合物胶囊载体的热响应性和生物降解。结果表明，DOX随着热处理迅速释放，PBS 5的DOX释放速率比PBS 7.4在PBS 5上的释放速率远远快。此外，水不溶性药物姜黄素的释放在GSH的辅助方面比没有。

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